Possible Association of HLA-DR and DQ Molecules with Autoimmune Hepatitis in Iraqi Patients

Authors

  • Eman Sh. AL-Obeidy Dept. of Virology, Medical Laboratory, Medical City.
  • Khalida M. Mousawy College of Medicine / University of Baghdad.
  • Raghad J H AL-Akayshi Gasteroentestinal and Hepatology Teaching Hospital.
  • Laith Abdalelah Al-Karama Teaching Hospital.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5211057

Keywords:

autoimmune hepatitis, Human leukocyte antigen (HLA), PCR –SSP assay.

Abstract

Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region seem to influence susceptibility to certain diseases.
Patients and methods: Polymerase chain reaction-Sequence Specific Primers PCR-SSP is the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: An increased frequency of HLA-DR3, DR4 and DR7 was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively, while DR*0211 (DR2) may be formed the basis for protection against the disease. HLA-DQ on the other hand, yielded on association in Iraqi patients with AIH.
Conclusions: This finding demonstrated that HLA-DR3, DR4 and DR7 might play a role in AIH susceptibility.

Downloads

Download data is not yet available.

Downloads

Published

2010-04-04

How to Cite

1.
Possible Association of HLA-DR and DQ Molecules with Autoimmune Hepatitis in Iraqi Patients. JFacMedBagdad [Internet]. 2010 Apr. 4 [cited 2024 Mar. 28];52(1):50-3. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1057

Similar Articles

1-10 of 282

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>