Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients

Eman Sh. AL-Obeidy; Khalida M. Mousawy; Raghad J H AL-Akayshi; Laith A. Kamil

doi:10.32007/jfacmedbagdad.5111170

Authors

Eman Sh. AL-Obeidy Medical city.
Khalida M. Mousawy Medical College/ University of Baghdad.
Raghad J H AL-Akayshi Gasteroentestinal and Hepatology Teaching Hospital.
Laith A. Kamil Al-Karama Teaching Hospital

DOI:

https://doi.org/10.32007/jfacmedbagdad.5111170

Keywords:

AIH, HLA antigen, PCR-SSP.

Abstract

Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis.
Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor.
Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out.