Increased Frequency of Complement C4 "Null" Alleles in Autoimmune Hepatitis
DOI:
https://doi.org/10.32007/jfacmedbagdad.5131131Keywords:
autoimmune hepatitis, HLA, C4A*Q0, Immunofixation test.Abstract
Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region influence susceptibility to certain diseases.
Patients and methods: Immunofixation test is the method used to asses C4 polymorphism of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: An increased frequency of C4A*Q0 was observed for patients group versus control group with P-value (0.003).
Conclusions: This finding demonstrated that C4A*Q0 might play a role in AIH susceptibility.
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