HLA prevalence in Iraqi patients with ischemic heart disease.

Authors

  • Basil N. AL-Dileamy Department of Medicine, College of Medicine, University of Baghdad.
  • Eman Sh. AL-Obeidy Department of immunology, center teaching laboratory, Baghdad Medical city.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5221018

Keywords:

Ischemic Heart Disease, Human Leukocyte Antigens.

Abstract

Background: The etiology of ischemic heart disease (IHD) is believed to have an immunological component. Association with human leukocyte antigens (HLAs) has been previously reported, particularly with DR6.
Patients and methods: 75 cardiac patients were admitted to the coronary care unit, Baghdad Teaching Hospital over the period October 2008-May 2009 with the clinical diagnosis of acute
coronary syndrome and STEMI myocardial infarction their ages range was (25-82) years the number of male was (55) (73.3%) and female was (20) (26.7%). All cases have routine ECG, cardiac marker’s measurements, routine haematological, Biochemical test and 2mls of blood reserved for HLA study.
Results: It was found that HLA-DR1 (8%) (P 0.001) has significant risk factor in the development of ischemic heart disease while HLA B (62%) (P 0.0009) has a protection factor in ischemic heart disease.
Conclusions: Our result suggests that strong relation between the incidence of acute ischemic episode (acute coronary syndrome and STEMS myocardial infarction and HLA-DR1) which mean that there may be predisposing genetic factor for the development ischemic heart disease.

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Published

04.07.2010

How to Cite

1.
AL-Dileamy BN, AL-Obeidy ES. HLA prevalence in Iraqi patients with ischemic heart disease. J Fac Med Baghdad [Internet]. 2010 Jul. 4 [cited 2024 Nov. 21];52(2):180-2. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1018

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