Hemostatic changes in patients with chronic renal failure

Abstract

Background: Renal disease results in significant disorder of hemostasis (bleeding diathesis or
hypercoagulable state).
Objectives: This study is to determine the changes in some hemostasis parameters in patients with
chronic renal failure and identify the effect of dialysis on these changes.
Patients and Methods: seventy five patients with end stage chronic renal failure were collected from
Baghdad hospital, a full detailed history and clinical examination were performed, 50 patients were on
maintenance weekly hemodialysis, and 25 patients were without dialysis.
Result: Bleeding time was significantly higher in patients with chronic renal failure who didn’t need
any type of dialysis, positive D-Dimer test. In some patients, Platelet count, prothrombin time, thrombin
time, fibrinogene level, activated partial thromboplastin time; all did not reach significant level between
both groups of patients.
Conclusion: hemostatic changes are not uncommon in patients with chronic renal failure, affecting the
different parameter hemostasis so it should be consider in the management of these patients.