Thyroid Disorders and the Level of Malondialdehyde

Authors

  • Eham A. Ali Department of Biochemistry, College of Medicine, Al-mustansyria University
  • Yildiz H. Tahseen Department of Phisyological chemistry, College of Medicine, University of Baghdad.
  • Hedef D. El-Yassin Department of Phisyological chemistry, College of Medicine, University of Baghdad.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5111179

Keywords:

Thyroid Disorders,malondialdehyde.

Abstract

Background: Free radicals have been implicated in many pathological processes, including ischemia, inflammation, and malignancy. The free radicals may affect tissues damage by lipid
peroxidation which generate malondialdehyde (MDA) as a by byproduct of the reaction. The objective of this study is to examine the dynamics of lipid peroxidation in patients with
thyroid disorders using the measurement of malondialdehyde level as a marker for the degree of thyroid disorder.
Methods: Two hundred and forty five subjects were enrolled in this study. Hundred and ninety five were patients with different thyroid disorders (88 yperthyroidism, 63 hypothyroidism and 44 thyroid carcinoma) the remaining 50 subjects were healthy ones without any apparent functional disorders served as a control. Malondialdehyde (MDA) level was estimated in the sera of all subjects.
Results: A significant increase in the level of serum MDA concentration was observed in patients with all types of thyroid disorders as compared with the control groups.
Conclusion: The findings obtained showed a high rate of lipid peroxidation.

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Published

01.04.2009

How to Cite

1.
Ali EA, Tahseen YH, El-Yassin HD. Thyroid Disorders and the Level of Malondialdehyde. J Fac Med Baghdad [Internet]. 2009 Apr. 1 [cited 2024 Nov. 13];51(1):67-70. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1179

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