Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection

  • Fadhil B. Shamkhi Biochemistry. Nephrology and Renal Transplantation Center, The Medical City, Baghdad, Iraq.
  • Ala Sh. Ali Biochemistry. Nephrology and Renal Transplantation Center, The Medical City, Baghdad, Iraq.
  • Hedef D. El-Yassin Dept. of Biochemistry, College of Medicine, Baghdad University. Email: [email protected]
Keywords: Cystatin C, Renal Transplantation, Acute Rejection.

Abstract

Background: Accurate and rapid assessment of allograft function is essential. Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate (GFR). Its diagnostic value for the longitudinal assessment of graft function has not been addressed well.
Objective: To study the validity of cystatin C as an early marker and predictor of acute transplant rejection in the first week post transplantation.
Subjects and Methods: Sixty six renal transplants recipients recruited. The study conducted in four renal transplantation centers in Baghdad for the period from September to December 2011. Serum creatinine and cystatin C concentrations measured 48 hours before transplantation and day 3 and 7 post transplantation.
Results: Serum Cystatin C observed to significantly increased at day 3 (p<0.0001) and still increased at day 7 in the rejection. On day 3 areas under the receiver operating characteristic (ROC) curves were 0.749 for creatinine and 0.909 for cystatin C. In patients with acute rejection, serum cystatin C level elevated earlier than serum creatinine.
Conclusion: Serum cystatin C seems to be a valuable marker of renal function in the first week post transplantation.

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Published
2015-10-01
How to Cite
1.
Shamkhi F, Ali A, El-Yassin H. Serum Cystatin C as a Predictor of Acute Kidney Transplant Rejection. JFacMedBagdad [Internet]. 1Oct.2015 [cited 9May2021];57(3):188-92. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/358