Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer: A follow up study

Authors

  • Zainab A. M. Ali Ibn Sena Teaching Hospital. Mosul.
  • Wasan K. Jasim Rozh Halat Emergency Hospital .Erbil.
  • Dilan Z.  Hussein Rozh Halat Emergency Hospital .Erbil.
  • Manwar     Abd.   Alnaqash Dept. of Surgery, College of Medicine/ Baghdad University

DOI:

https://doi.org/10.32007/jfacmedbagdad.603602

Keywords:

Breast cancer, Tamoxifen, the lipid profile, premenopausal women.

Abstract

 Background: Breast cancer composed of several biologic subtypes that have response to hormonal therapy. Tamoxifen is  hormonal therapy  with tissue- pecific antagonistic or agonist effects, the latter being responsible for multiple  effects on lipid metabolism in women .

Objective: This study was designed to determine the impact of Tamoxifen on the serum lipid profile in breast cancer women. 

Patients and methods: Prospective observation cohort study conducted at Oncology Teaching Hospital, Medical city complx.starting from October 2015 to October 2016. A total number of 40 premenopausal women with breast cancer   were enrolled in this study according to inclusion criteria . Patients were followed for three months by the measurements TC, TG, HDL – cholesterol and BMI .

Results: At the end of third months of hormonal therapy, Tamoxifen showed a significant decrease in TG, VLDL (p< 0.001 for both).  On the other side HDL and BMI  showed significant increase over three months duration , (p = 0.001  and 0.006, respectively) .

Conclusion: Beneficial alterations of lipid profiles were seen in pre-menopausal breast cancer patients treated with Tamoxifen.                                                          

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Author Biographies

  • Zainab A. M. Ali, Ibn Sena Teaching Hospital. Mosul.

    FIBMS CP

  • Wasan K. Jasim, Rozh Halat Emergency Hospital .Erbil.

    FIBMS  CP

  • Dilan Z.  Hussein, Rozh Halat Emergency Hospital .Erbil.

      FIBMS CP

  • Manwar     Abd.   Alnaqash, Dept. of Surgery, College of Medicine/ Baghdad University

       DMRT MSc (Pathology)

     

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Published

2018-12-31

How to Cite

1.
Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer: A follow up study. JFacMedBagdad [Internet]. 2018 Dec. 31 [cited 2024 Mar. 29];60(3):141-4. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/602

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