Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer: A follow up study

Abstract

 Background: Breast cancer composed of several biologic subtypes that have response to hormonal therapy. Tamoxifen is  hormonal therapy  with tissue- pecific antagonistic or agonist effects, the latter being responsible for multiple  effects on lipid metabolism in women .

Objective: This study was designed to determine the impact of Tamoxifen on the serum lipid profile in breast cancer women. 

Patients and methods: Prospective observation cohort study conducted at Oncology Teaching Hospital, Medical city complx.starting from October 2015 to October 2016. A total number of 40 premenopausal women with breast cancer   were enrolled in this study according to inclusion criteria . Patients were followed for three months by the measurements TC, TG, HDL – cholesterol and BMI .

Results: At the end of third months of hormonal therapy, Tamoxifen showed a significant decrease in TG, VLDL (p< 0.001 for both).  On the other side HDL and BMI  showed significant increase over three months duration , (p = 0.001  and 0.006, respectively) .

Conclusion: Beneficial alterations of lipid profiles were seen in pre-menopausal breast cancer patients treated with Tamoxifen.