Evaluation of the Effect of Type II Diabetes mellitus on Bone Mineral Density of Upper and Lower Limbs by Dual-Energy X-Ray Absorptiometry

Authors

  • Zainb A. Abdel Aziz Department of Physiology, College of Medicine, University of Baghdad, Baghdad, Iraq
  • Numan S. Dawood Department of Physiology, College of Medicine, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-5064-7051
  • Maan H. Al-Khalisy Department of Anatomy, College of Medicine, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.32007/jfacmedbagdad.6511980

Keywords:

DEXA scan, Osteoporosis, DMII, BMD

Abstract

Background: Bone mineral density has been assessed using Dual-Energy X-Ray Absorptiometry. Bone mineral density is measured according to the results of the Dual-Energy X-Ray Absorptiometry examination of the vertebral column and pelvis. Although diabetes mellitus type II (DM) is known to affect bone mineral density, at the present time this particular relationship is not clear.

 Objective: The aim of current study was to evaluate the effects of type II diabetes mellitus on bone mineral density of the upper and lower limbs as well as gender differences.  

Patients and Methods: This study involved 165 patients complaining of bone pain (85 males and 80 females), 85 patients of who suffered from diabetes, involving both genders. In addition, 90 apparently healthy volunteers had been studied and were considered to constitute the control group. All individuals (255) were studied regarding their bone mineral density via Dual-Energy X-Ray Absorptiometry for all parts of the body.

Results: The Dual-Energy X-Ray Absorptiometry exam revealed highly statistically significant differences between the sides of the body in the same person. In addition, there were significant differences in bone mineral density between females and males, as well as between the control and patient groups with type II diabetes mellitus.

 Conclusion: Our results indicated that the bone mineral density of women was less than that in men in all cases (normal, osteoporosis, and diabetes mellitus type II (DM) with osteoporosis). Other results obtained from this research revealed that diabetes mellitus type II (DM) can be considered to be one of the major causes of osteoporosis in the general population

Downloads

Download data is not yet available.

References

- Elena F. Kranioti, Andrea Bonicelli, Julieta G García-Donas Bone-mineral density: clinical significance, methods of quantification and forensic applications. Research and Reports in Forensic Medical Science. 2019; 9:9-21.

- Aleksandra Gonera-Furman, Marek Bolanowski, and Diana Jędrzejuk, Osteosarcopenia—The Role of Dual-Energy X-ray Absorptiometry (DXA) in Diagnostics, J Clin Med.;2022, 11(9): 2522.

- Lohman M, Tallroth K, Kettunen JA, Marttinen MT. Reproducibility of dual-energy x-ray absorptiometry total and regional body composition measurements using different scanning positions and definitions of regions. Metabolism. 2009; 58(11):1663-8

- Glüer CC. 30 years of DXA technology innovations. Bone. 2017;104:7–12.

- Shepherd JA, Ng BK, Sommer MJ, et al . Body composition by DXA. Bone. 2017;104:101–105.

- Garg MK and Kharb S. Dual energy X-ray absorptiometry: Pitfalls in measurement and interpretation of bone mineral density. Indian J Endocrinol Metab. 2013;17:203–210.

- Lindsay R, Silverman SL, Cooper C, et al. Risk of new vertebral fracture in the year following a fracture. JAMA. 2001;285:320–323.

- Hamdi, Rana A. "Evaluation of Serum Osteocalcin level in Iraqi Postmenopausal women with primary osteoporosis." Journal of the Faculty of Medicine Baghdad, 2013: 55 (2):166-169.

- Bilha, S.C., Leustean, L., Preda, C., et al. Bone mineral density predictors in long-standing type 1 and type 2 diabetes mellitus. BMC Endocr Disord,2021: 21, 156.

- Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes – A meta-analysis. Osteoporos Int. 2007;18:427–44.

- Mohammed Abusaib, Mazyar Ahmed, Hussein Ali Nwayyir . et al., Iraqi Experts Consensus on the Management of Type 2 Diabetes/Prediabetes in Adults. Clin Med Insights Endocrinol Diabetes. 2020 ;13:( PMC7440731).

- Ameya Joshi, Premlata Varthakavi, Manoj Chadha, et al. A study of bone mineral density and its determinants in type 1 diabetes mellitus. Journal of Osteoporosis. 2013, |Article ID 397814|.

- Cosman F, de Beur SJ, LeBoff MS,, et al. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25:2359–81.

- Jeddi S, Yousefzadeh N, Kashfi K, et al., Role of nitric oxide in type 1 diabetes-induced osteoporosis, Biochem Pharmacol. 2022;197: 114888.

- Maede Hasanpour, Milad Iranshahy and Mehrdad Iranshahi, The application of metabolomics in investigating anti-diabetic activity of medicinal plants, Biomedicine & Pharmacotherapy. 2020; 128, 110263.

- Yazici, S., Korkmaz, U., Erkan, M., et al., The effect of breast-feeding duration on bone mineral density in postmenopausal Turkish women: a population-based study. Archives of medical science : AMS, 2011: 7(3), 486–492.

- Kanis JA, McCloskey EV, Johansson H, et al, A reference standard for the description of osteoporosis, Bone. 2008, 42, (3), pp. 467–475.

- Hwang IR, Choi YK, Lee WK,, et al. Association between prolonged breastfeeding and bone mineral density and osteoporosis in postmenopausal women: KNHANES 2010-2011. Osteoporos Int. 2016;27(1):257–265.

- May F. Saleh, Ammar H. Ahmed, and Jawad K. Al-Diwan. Possible relationships of selected food items to osteoporosis among a group of Iraqi women. Journal of the Faculty of Medicine 63.4 (2021).

- Gur A, Nas K, Kayhan O, et al. The relation between tooth loss and bone mass in postmenopausal osteoporotic women in Turkey: a multicenter study. J Bone Miner Metab. 2003;21:43–7.

- McArdle WD, Katch FI and Katch VL,. Exercise Physiology: Nutrition, Energy, and Human Performance: Lippincott Williams & Wilkins; 2010.

- Moyer-Mileur, L. J., Slater, H., Jordan, K. C., et al. IGF-1 and IGF-binding proteins and bone mass, geometry, and strength: Relation to metabolic control in adolescent girls with type 1 diabetes. J Bone Miner Res. 2008;23:188–91.

- 20- Ghudhaib, Kadhim K., Kismat M. Turaki, and Sabreen A. Muzal, Estimation of Serum Osteocalcin Levels in Osteoporotic Postmenopausal Iraqi Women with Type 2 Diabetes Mellitus. Baghdad Science Journal.2014; 11(4): 1-7.

Downloads

Published

27.04.2023

How to Cite

1.
Abdel Aziz ZA, Dawood NS, Al-Khalisy MH. Evaluation of the Effect of Type II Diabetes mellitus on Bone Mineral Density of Upper and Lower Limbs by Dual-Energy X-Ray Absorptiometry. J Fac Med Baghdad [Internet]. 2023 Apr. 27 [cited 2024 Nov. 22];65(1):27-33. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1980

Publication Dates

Similar Articles

1-10 of 50

You may also start an advanced similarity search for this article.