Anti-Liver membrane Antibody predict outcome of Autoimmune Hepatitis

Eman Sh. AL- Obeidy; Batool A. Al-Haidary; Akram A. Najeeb

doi:10.32007/jfacmedbagdad.5031265

Authors

Eman Sh. AL- Obeidy immunology, Medical City.
Batool A. Al-Haidary College of Medical & Health Technology/ University of Baghdad.
Akram A. Najeeb Gastroenterology and Liver Disease / Teaching Hospital.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5031265

Keywords:

Anti-Liver membrane

Abstract

Background: Autoantibodies against liver membrane are the specific autoantibodies found in AIH. Cytochrome P450 1A2 has been identified as the
target autoantigen for these autoantibodies
The aim of the study : is to evaluate the prevalence and clinical relevance of LMA in AIH
Methods: The study was performed on 73 Iraqi patients with chronic active hepatitis (CAH) of unknown cause , attending the teaching hospital for gastroenterology and
liver disease in a period between November 2003 and July 2004. Anti-liver membrane antibodies were studied by IFA technique.
Results: LMA was detected in the sera of 28(57.14)and 3(37.5%) patients with type 1 and type 3 AIH respectively, but never in the sera of healthy group .
Conclusion: It was concluded that LMA is present in type-1 and type-3 AIH but not in sera of patients with type-2 or in healthy control group.