Possible Role for Interleukin-5 in Asthma

Yacoob Y. Al-Rubaeyi; Batool A. Al-Haidary; Wala'a E. Jasim

doi:10.32007/jfacmedbagdad.4841473

Authors

Yacoob Y. Al-Rubaeyi Medical Laboratory Science / College of Medical & Health Technology.
Batool A. Al-Haidary Clinical Immunology ,College of Medical & Health Technology.
Wala'a E. Jasim Biochemistry , College of Medical & Health Technology.

DOI:

https://doi.org/10.32007/jfacmedbagdad.4841473

Keywords:

Asthma, IL-5, bronchitis, Eosinophilia, IgE

Abstract

Background: Asthma is an allergic disease characterized by airway obstruction as a result of cellular accumulation due to the liberation of certain mediators. Among those mediators are the cytokines such as IL-5.
Patients & Methods: Interleukin-5 concentration has been estimated in 94 sera samples of Asthmatic patients in comparison with 41 non-asthmatic bronchitis as patient controls in addition to 30 apparent healthy control group using ELISA method.
Results & Conclusions: There is highly significant elevation of IL-5 in the asthmatic cases in comparison with healthy controls (P< 0.001). We conclude that this cytokine may play the major
role in asthmatic attack & it may be a good marker for the disease.