The expression of Matrix metalloproteinase-2 and cyclooxygenase-2 by immunohistochemistry in patients with colorectal carcinoma

Authors

  • Areej A. Hussein Dept. of Microbiology, College of Medicine, Diyala Unversity.
  • Basim M. Ibrahim Dept. of Oral Pathology, College of Dentist, University of Baghdad.
  • Basim M. Kashman Dept. of Microbiology, College of Medicine, University of Baghdad.

DOI:

https://doi.org/10.32007/jfacmedbagdad.533834

Keywords:

Colorectal neoplasm, Matrix metalloproteinase-2, Cyclooxygenase-2, Metastasis

Abstract

Background: Human colorectal carcinogenesis is a complex, multistep and multigenetic process. Matrix metalloproteinase-2 and cyclooxygenase-2 are key enzyme in degradation of extracellular material, are over expressed in several epithelia like colorectal adenocarcinoma.
Objectives: This study was designed to detect the expression of matrix metalloproteinase-2 and cyclooxygenase-2 in patients with colorectal carcinoma and their correlation with age, gender, tumor grade and presence or absence of muscle invasion.
Materials and methods: Immunohistochemical staining of MMP-2 and COX-2 was determined in 40 tissue samples from colorectal patients, from teaching laboratories in Baghdad medical city. In addition twelve apparently normal colorectal autopsies were used as a control group.
Results: The expression of matrix metalloproteinase-2 was detected in 30 of 40 colorectal cancer cases (75%) while cyclooxygenase-2 was detected in 31 0f 40 colorectal cancer cases (77.5%). All normal colorectal specimens showed negative results. The incidence of both of them was higher for grade II than those in earlier grade.
Conclusion: Cancer cells to have a more aggressive behavior may show an up regulation of tumor cell derived matrix metalloproteinase-2 and cyclooxygenase-2.

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Published

2011-10-02

How to Cite

1.
The expression of Matrix metalloproteinase-2 and cyclooxygenase-2 by immunohistochemistry in patients with colorectal carcinoma. JFacMedBagdad [Internet]. 2011 Oct. 2 [cited 2024 Mar. 29];53(3):301-5. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/834

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