Evaluation of signs of immune or metabolic disturbances among diabetic patients with positive islet cell antibodies

Authors

  • Zhian M. Ibrahim Dezayee Dept. of Immunology, College of Medicine, Hawler Medical University
  • Nabeel E. Waheda Dept. of Immunology, College of Medicine, Hawler Medical University
  • Sabria M. Said Al- Salihi Dept. of Immunology, College of Medicine, Hawler Medical University

DOI:

https://doi.org/10.32007/jfacmedbagdad.541773

Keywords:

Islet cell antibodies, lipid profile, immunoglobulins

Abstract

Background: Autoantibodies to islet cell antigens are known predictors of type 1 diabetes and detected in latent autoimmune diabetes in adults.
Objectives: This study aimed to identify the metabolic and immunological disturbances in diabetic patients with positive and negative islet cell antibodies (ICAs)
Materials and methods: A total number of 235 known cases of diabetes mellitus type 1 (160) and type 2 diabetes (75) were admitted in the study. Serum ICA and immunoglobulins (IgA, IgM, IgG) as well lipid profile were measured.
Results: Positive ICAs was found in 40 out of 120 T1D (33.3%) and 28 out of 75 T2D (37.3%). All the patients were poorly controlled diabetes with the evidence of significant high HbA1c%. There were no significant differences in the lipid profile or immunoglobulin levels between positive and negative ICAs in T1D and T2D.
Conclusions: Autoimmunity in term of positive ICA does not play a role in metabolic or immunologic disturbances that associated with T1D and T2D.

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Published

2012-04-01

How to Cite

1.
Evaluation of signs of immune or metabolic disturbances among diabetic patients with positive islet cell antibodies. JFacMedBagdad [Internet]. 2012 Apr. 1 [cited 2024 Mar. 28];54(1):63-7. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/773

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