Homestasis Model Assessment–Adiponectin ratio and Adiponectin –Resistin index as markers of insulin resistance in type 2diabetes mellitus

Authors

  • Ikhlas Khalid Hameed Dept. of Clinical Biochemistry, Al-kindy Medical College, Baghdad University.
  • Nada F. Rashid Dept. of Clinical Biochemistry, Al-kindy Medical College, Baghdad University.
  • Baydaa A. Abed National Diabetic Center, Al-Mustansiria University.

DOI:

https://doi.org/10.32007/jfacmedbagdad.552650

Keywords:

HOMA- Adiponectin, Adiponectin –Resistin index , insulin resistance ,type 2diabetes mellitus.

Abstract

Background: Insulin resistance (IR) is an important clinical and biochemical determinant of diabetes and many other clinical states. The gold standard method for IR estimation is the hyperinsulinemic euglycaemic glucose clamp. Adiponectin and resistin are adipocytes derived hormones that play important role in the regulation of glucose, fat metabolism and insulin resistance.
Objective: this study aimed to assess the validity of Homestasis Model Assessment–Adiponectin ratio and Adiponectin –Resistin index as markers of insulin resistance in type 2 diabetic mellitus (T2DM) patients.
Design: Ninety (T2DM) overweight male subjects were enrolled in this cross sectional study, detailed history, physical examination and anthropometric measures including BMI, waist, and hip circumference were done to all the participants. Fasting serum samples were obtained and used for the measurement of serum glucose, serum triglyceride, high density lipoprotein(HDL),very low density lipoprotein(VLDL),HbA1c ,also serum insulin, adiponectin ,resistin were measured and HOMA-IR, HOMA-AD and AR-index were calculated.SPSS-17 was used to analyze the data.
Results: AR-index correlates significantly with FSG, Fasting Insulin and HOMA-IR (r =0.534.p=0.005), (r=0.545, p=0.005), (r=0.506, p=0.008) respectively HOMA-AD correlates with FSG (R=0.551, P=0.001), insulin (P=0.956,p=0.000),HOMA-IR(r =0.952, p=0.000). AUC for AR-index (0.800) and for HOMA-AD (0.905).
Conclusions: HOMA-AD and AR-index are reliable and valid measures for the assessment of insulin resistance in type 2 diabetic patients.

Downloads

Download data is not yet available.

Downloads

Published

01.07.2013

How to Cite

1.
Khalid Hameed I, Rashid NF, Abed BA. Homestasis Model Assessment–Adiponectin ratio and Adiponectin –Resistin index as markers of insulin resistance in type 2diabetes mellitus. J Fac Med Baghdad [Internet]. 2013 Jul. 1 [cited 2024 Nov. 14];55(2):175-8. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/650

Publication Dates

Similar Articles

1-10 of 427

You may also start an advanced similarity search for this article.