Evaluation of some Biochemical and Hematological Parameters in Patients with Chronic Kidney Disease
DOI:
https://doi.org/10.32007/jfacmedbagdad.2269Keywords:
Chronic Kidney disease, Cystatin C, Hematological, HemoglobinAbstract
Background: Chronic kidney disease is a condition that results from an indefinite change in the structure and function of the kidneys. A slow, steady progression characterizes it and is irreversible.
Objectives: This study aims to evaluate the findings of certain biochemical and hematological tests in samples from Iraqi CKD patients.
Methods: This study included 90 subjects, where 70 patients with chronic kidney disease and 20 healthy individuals. Blood samples were collected from the patients during their visits to Ghazi Al-Hariri Surgical Specialties' Hospital- Medical City, Baghdad, Iraq. Age, sex and body mass index were assessed for each participant followed by renal function tests [serum blood urea, creatinine, uric acid and estimated glomerular filtration rate], and complete blood count. Also, serum levels of uromodulin and cystatin C were measured statistically studies were carried out using analysis of variance (ANOVA).
Results: the study demonstrated a highly significant (P<0.001) increase in blood urea, serum creatinine and uric acid levels, while a significant (P<0.05) decrease in estimated glomerular filtration rate levels in patients compared to the control group. On the other hand, it showed a highly significant (P<0.001) decrease in hemoglobin and hematocrit values and a significant (P<0.05) decrease in the red blood cell count. Patients had revealed a significant (P<0.05) increase in cystatin C level and a decrease in uromodulin level when compared to the control group.
conclusion: the present study shows that chronic kidney disease patients have upregulated renal function parameters blood urea, serum creatinine and with downregulated estimated glomerular filtration rate, while hematological disorder was more prevalent in patients. On the other hand, cystatin C level revealed an increase while uromodulin level showed a decrease in Iraqi patients.
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Ledoux MP, Guffroy B, Nivoix Y, Simand C, Herbrecht R. Invasive Pulmonary Aspergillosis. Semin Respir Crit Care Med. 2020; 41(01):080–98. http://doi/10.1055/s-0039-3401990.
Shafiq SA, Al-Joofy AK. Histopathological and enzymatic study on the effect of Aspergillus fumigatus in mice. J Fac Med Baghdad 2010; 52(4). https://doi.org/10.32007/jfacmedbagdad.524962
Mansoor NT, Jalil MJ, Yahya ASM, Abbas LM, Salman MD. Effects of contaminated feed with Aspergillus flavus on some hematological and biochemical parameters on Cyprinus carpio L. 1758. Iraqi J Vet Med. 2018; 42(1):87–91. https://doi.org/10.30539/iraqijvm.v42i1.36
Al-Charrakh AH, Al-Mamory ZO, Al-Malaky KA. Antifungal susceptibility patterns of Aspergillus species isolated from patients with pulmonary diseases in Iraq. J Appl Pharm Sci. 2018; 8(5):088–93. URL
Abomughaid MM. Isolation and identification of fungi from clinical samples of diabetic patients and studying the anti-fungal activity of some natural oils on isolated fungi. Baghdad Sci J. 2021; 18(3):0462–0462. https://doi.org/10.21123/bsj.2021.18.3.0462
Ardi P, Daie-Ghazvini R, Hashemi SJ, Salehi MR, Bakhshi H, Rafat Z, et al. Study on invasive aspergillosis using galactomannan enzyme immunoassay and determining antifungal drug susceptibility among hospitalized patients with hematologic malignancies or candidates for organ transplantation. Microb Pathog. 2020; 147:104382. https://doi.org/10.1016/j.micpath.2020.104382
Aldeen Muhammed MS, Al-Attraqchi AAF, Dawood HN, Hamed Hameed G. Detection of Aspergillus spp. and Candida albicans antigenemia in a sample of Iraqi patients with severe COVID-19. J Emerg Med Trauma Acute Care. 2022; (3). https://doi.org/10.5339/jemtac.2022.ismc.7
Jawad MA, Alkharasani AAH, Zanki FA, AL-Janabi AAHS, Ali RN. Advantages and disadvantages usage of Galactomannan ELISA assay for detection of Aspergillosis. Int J. 2019; 2(6):50. URL
Hsiao HH, Liu YC, Wang HC, Du JS, Tang SH, Yeh TJ, et al. Comparison of a novel lateral-flow device to galactomannan assay at different time periods for detections of invasive aspergillosis. J Formos Med Assoc. 2022; 121(10):2123–9. https://doi.org/10.1016/j.jfma.2022.04.011
Lai G, Zeng C, Mo J, Song W dong, Xu P. Diagnostic Value of Galactomannan in Bronchoalveolar Lavage Fluid for Chronic Respiratory Disease with Pulmonary Aspergillosis. Fenwick B, editor. J Clin Microbiol. 2020 Feb 24; 58(3):e01308-19. https://journals.asm.org/doi/10.1128/JCM.01308-19
Mercier T, Dunbar A, de Kort E, Schauwvlieghe A, Reynders M, Guldentops E, et al. Lateral flow assays for diagnosing invasive pulmonary aspergillosis in adult hematology patients: a comparative multicenter study. Med Mycol . 2020; 58(4):444–52. https://doi.org/10.1093/mmy/myz079
Kindo A. P457 Clinical correlation of beta galactomannan with culture and patient outcome in a tertiary care center in south india. Med Mycol. 2022; 60 (1). https://doi.org/10.1093/mmy/myac072.P457
Aerts R, Mercier T, Maertens J, Lagrou K. P412 QuicGM Aspergillus Galactomannan Ag lateral flow assay as a practical aid to diagnose invasive Aspergillosis in high-risk hematology patients. Med Mycol. 2022; 60(1) 072P412. Available from: URL
Liu C, Peng J, Zhang Y, Wang Y, Wang H, Su Y, et al. P460 The Aspergillus Lateral Flow Assay for the diagnosis of invasive Aspergillosis. Med Mycol 60(1) 072P460. https://doi.org/10.1093/mmy/myac072.P460
Serin I, Dogu MH. Serum Aspergillus galactomannan lateral flow assay for the diagnosis of invasive aspergillosis: A single‐centre study. Mycoses. 2021; 64 (6): 678–83. https://onlinelibrary.wiley.com/doi/10.1111/myc.13265
Jenks JD, Miceli MH, Prattes J, Mercier T, Hoenigl M. The Aspergillus Lateral Flow Assay for the Diagnosis of Invasive Aspergillosis: an Update. Curr Fungal Infect Rep. 2020;14(4):378–83. URL
Aerts R, Cuypers L, Mercier T, Maertens J, Lagrou K. Implementation of Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis in European Hospitals: A Survey from Belgium and a Literature Review of Test Performances in Different Patient Populations. Mycopathologia. 2023; 188(5): 655–65. URL
Priya H, Kothari N, Jain V, Kumar D, Khichar S, Rohila AK, et al. P447 Galactomannan lateral flow assay for the diagnosis of invasive Aspergillosis among clinically suspected patients in tertiary care center, Jodhpur, Rajasthan. Med Mycol. 2022; 60 (1) 46. https://doi.org/10.1093/mmy/myac072.P460
Alhan O, Saba R, Akalin EH, Ener B, Ture Yuce Z, Deveci B, et al. Diagnostic Efficacy of Aspergillus Galactomannan Lateral Flow Assay in Patients with Hematological Malignancies: A Prospective Multicenter Study. Mycopathologia. 2023; 188(5):643–53. URL
Taghavi M, Mortaz E, Nikaein D, Athari S. Significance of galactomannan antigen for Aspergillosis diagnosis: A review. J Mycol Res. 2015; 2(2):111–7. URL
Shariati A, Moradabadi A, Chegini Z, Khoshbayan A, Didehdar M. An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies. Infect Drug Resist. 2020; 13:2329–54. URL https://doi.org/10.2147/IDR.S254478
Ali R, AL-Wattar WMA, Jawad AM. Detection of Galactomannan Antigen in the Serum of Iraqi Patients with Suspected Invasive Aspergillosis. J Fac Med Baghdad. 2016; 58(1):71–4. https://doi.org/10.32007/jfacmedbagdad.581200
Al-Wattar WMA. Overview on common fungal infections, recovered in Baghdad teaching hospitals in five years. Iraq Med J. 2020;4(2). https://doi.org/10.22317/imj.v4i2.819
Al-Rawazq HS, Mohammed AK, Al-Zubaidy RH. Bacterial Isolates in Blood Culture of Children with Septicemia. J Fac Med Baghdad. 2012; 54(1):96–9. https://doi.org/10.32007/jfacmedbagdad.541781
Sato S, Kamata W, Fukaguchi K, Tsunoda S, Kamio T, Koyama H, et al. Successful treatment of invasive tracheobronchial pulmonary aspergillosis with venovenous extracorporeal membrane oxygenation and combined systemic, intratracheal instillation of liposomal amphotericin B: a case report. J Med Case Reports . 2022 16(1):470.URL
Al-Watar WMA, Al-Fakar SA, Mohammed KIA, Ali SHM. Anti Fungal Resistance of Some Yeasts Recovered in a Group of Immuno Compromised Patients. URL
Tunccan OG, Aki SZ, Akyurek N, Sucak G, Senol E. Isolated cutaneous aspergillosis in an acute lymphoblastic leukemia patient after allogeneic stem cell transplantation. J Infect Dev Ctries. 2011; 5(05):406–9. https://doi.org/10.3855/jidc.1466
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