Serum antioxidant status in Iraqi women with endometrial cancer

Salwa H. N. Al- Ruba,ei; Rana K. Jasim; Khudhair J. S. Al-Rawaq

doi:10.32007/jfacmedbagdad.584289

Authors

Salwa H. N. Al- Ruba,ei Dept. of Chemistry, College of Science, Al-Mustansiriya University.
Rana K. Jasim Dept. of Chemistry, College of Science, Al-Mustansiriya University
Khudhair J. S. Al-Rawaq Dept . of Surgery, College of Medicine, Baghdad University

DOI:

https://doi.org/10.32007/jfacmedbagdad.584289

Keywords:

Endometrial cancer, Vitamin A, Vitamin C, Vitamin E, β-carotene, Uric acid, MDA and Coenzyme Q10.

Abstract

Background: Endometrial cancer is the most common gynecologic malignancy in the United States and the fourth most common cancer in women, comprising 6% of female cancers.
Objectives: The aim of this study is to investigate the antioxidant vitamins, Coenzyme Q10 and oxidative stress in patients with endometrial cancer.
Patients and methods: Fifty six endometrial cancer women patients with various clinical stages (stage 1A, stage1B, stage II, stage III, stage IV) mean aged 58.055 ± 10.561 years, and 30 healthy women volunteers mean aged 39.731 ± 13.504 years, were includes as control group.
Results: The results in this study revealed a highly significant decreased (P<0.01) in β- carotene, Vitamin E and significant increased (P<0.01) in (Uric acid and MDA). The results of ( Coenzyme Q10 and Vitamins (A, C) showed a significant decreased (P<0.05), in the sera levels of patients with endometrial cancer as compared to control group.
Conclusions: This study suggest that high levels of oxidative stress and low levels of antioxidant defense system may be associated with increased the risks of endometrial cancer.