Serum antioxidant status in Iraqi women with endometrial cancer

  • Salwa H. N. Al- Ruba,ei Dept. of Chemistry, College of Science, Al-Mustansiriya University.
  • Rana K. Jasim Dept. of Chemistry, College of Science, Al-Mustansiriya University
  • Khudhair J. S. Al-Rawaq Dept . of Surgery, College of Medicine, Baghdad University
Keywords: Endometrial cancer, Vitamin A, Vitamin C, Vitamin E, β-carotene, Uric acid, MDA and Coenzyme Q10.

Abstract

Background: Endometrial cancer is the most common gynecologic malignancy in the United States and the fourth most common cancer in women, comprising 6% of female cancers.
Objectives: The aim of this study is to investigate the antioxidant vitamins, Coenzyme Q10 and oxidative stress in patients with endometrial cancer.
Patients and methods: Fifty six endometrial cancer women patients with various clinical stages (stage 1A, stage1B, stage II, stage III, stage IV) mean aged 58.055 ± 10.561 years, and 30 healthy women volunteers mean aged 39.731 ± 13.504 years, were includes as control group.
Results: The results in this study revealed a highly significant decreased (P<0.01) in β- carotene, Vitamin E and significant increased (P<0.01) in (Uric acid and MDA). The results of ( Coenzyme Q10 and Vitamins (A, C) showed a significant decreased (P<0.05), in the sera levels of patients with endometrial cancer as compared to control group.
Conclusions: This study suggest that high levels of oxidative stress and low levels of antioxidant defense system may be associated with increased the risks of endometrial cancer.

Downloads

Download data is not yet available.
Published
2016-01-03
How to Cite
1.
Al- Ruba,ei S, Jasim R, Al-Rawaq K. Serum antioxidant status in Iraqi women with endometrial cancer. JFacMedBagdad [Internet]. 3Jan.2016 [cited 11May2021];58(4):378-83. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/289