Changes in levels of Interleukin-6 (IL-6) and Interleukin-8 (IL-8) in the Serum of Preterm Delivery Pregnant Women Affected by Gingivitis

Shaden Husham; Ghada Taha

doi:10.32007/jfacmedbagdad.2152

Authors

Shaden Husham University of Baghdad https://orcid.org/0009-0003-5787-995X
Ghada Taha https://orcid.org/0000-0002-1958-1939

DOI:

https://doi.org/10.32007/jfacmedbagdad.2152

Keywords:

Gingivitis, Periodontal disease, preterm delivery, full term-delivery, Interleukine-6, Interleukin-8

Abstract

Background: Periodontal disease increases local and systemic inflammatory responses in pregnant women, which may lead to premature delivery.

Objectives: To detect maternal serum levels of proinflammatory cytokine (Interleukine-6, Interleukin-8) with preterm delivery in pregnant women suffering from gingivitis.

Cases and methods: In this case-control study, a total of 85 pregnant women, were included in the study, of whom 55 had gingivitis: 25 preterm deliveries and 30 full-term deliveries. Thirty healthy pregnant women with healthy gingiva were in the control group. They were selected from Al-Ramadi Teaching Hospital for Gynecology and Pediatrics, from November 2022 to May 2023. Blood samples were collected from all participants and the biomarkers cytokines were detected by immunosorbent assay ( ) kits.

Results: The current study showed an increased level of interleukin-6 and interleukin-8 in the pre-term delivery gingivitis group followed by full-term-delivery pregnant groups having gingivitis compared with the control group, with statistically highly significant differences ( ).

Conclusion: Pregnant women with gingivitis with the highest levels of Interlukine-6 and Interlukine-8 were more prone to have premature delivery than those with lower levels of Interleukins and those without gingivitis.

Received: June, 2023

Accepted: Aug, 2023

Published: Jan..2024

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