The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient

Authors

DOI:

https://doi.org/10.32007/jfacmedbagdad.1979

Keywords:

vitamin D3, , diabetes mellitus,, DMT1, , diabetic nephropathy (DNP)

Abstract

Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's renoprotective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney disease.

Objective: to evaluate the role of vit D on renal function in patient with DMT1.

Patient and Method: The total number of study participants was 120, divided into three groups: Group A: Included 40 patients has DM with NP (stage1, stage 2, stage 3a), Group B included 40 patients had DM without NP, and group C included 40 healthy participants (control). Samples were taken from the Diabetic control clinic of Endocrinology and Diabetes center/Al-Kinde Hospital, Baghdad Teaching Hospital/ Medical City and Al-Shaheed Al- Sadder General Hospital during the period from October 2021 to March 2022. 

Result: Statistically significant weak positive correlations were detected between vitamin D and GFR (r= 0.321, P= 0.001); while significant moderate negative correlation was seen between vitamin D and HbA1c (r= -0.494, P= 0.001) and weak negative correlation was seen with B. Urea (r= -0.2, P= 0.028). No statistically significant correlations detected between vitamin D and all of age, DM duration, and s. creatinine.

Conclusion: Our data suggest a correlation between reduced levels of vitamin D3 and diabetes nephropathy and it may be a potential predictor for both the occurrence and severity of diabetic nephropathy

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Published

01.07.2023

How to Cite

1.
Mijbel NA, Ibrahim SJ. The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient. J Fac Med Baghdad [Internet]. 2023 Jul. 1 [cited 2024 Dec. 21];65(2):93-7. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1979

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