The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient
العلاقة بين فيتامين د واعتلال الكلية السكري
DOI:
https://doi.org/10.32007/jfacmedbagdad.1979Keywords:
vitamin D3, diabetes mellitus, DMT1, diabetic nephropathyAbstract
Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's Reno protective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney diseases
Aim of the study: to evaluate the role of vit. D on renal function in patients with DMT1.
Patient and Method: The total number of study participants was 120, divided into three groups: Group A: Included 40 patients have DM with NP (stage1, stage 2, stage 3a), Group B included 40 patients who had DM without NP, and group C included 40 healthy participants (control). Samples were taken from the Diabetic control clinic of Endocrinology and Diabetes Center/Al-Kindy Hospital, Baghdad Teaching Hospital/ Medical City, and Al-Shaheed Al-Sadder General Hospital during the period from October 2021 to March 2022.
Result: Statistically significant weak positive correlations were detected between vitamin D and GFR (r= 0.321, P= 0.001); while a significant moderate negative correlation was seen between vitamin D and HbA1c (r= -0.494, P= 0.001) and weak negative correlation was seen with B. Urea (r= -0.2, P= 0.028). No statistically significant correlations were detected between vitamin D and all of age, DM duration, and s. creatinine.
Conclusion: Our data suggest a correlation between reduced levels of vitamin D3 and diabetes nephropathy and it may be a potential predictor for both the occurrence and severity of diabetic nephropathy
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References
-Saleh MM, Dhamad GD, Kamel LA. Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus. Journal of the Faculty of Medicine Baghdad. 2014; 56(4):401-4. 2-Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Research International. 2021 Jul 9; 2021. 3-Hamdi RA, Abdul-Qahar ZH, Kadhum EJ, Alsaeed FA. Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome. Journal of the Faculty of Medicine Baghdad. 2018 Sep 2; 60(2):93-7 4-Mazanova A, Shymanskyi I, Lisakovska O, Hajiyeva L, Komisarenko Y, Veliky M. Effects of cholecalciferol on key components of vitamin D-endo/para/autocrine system in experimental type 1 diabetes. International Journal of Endocrinology. 2018 Feb 6; 2018.
-Galuška D, Pácal L, Kaňková K. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. Kidney and Blood Pressure Research. 2021; 46(2):152-61. 6-Paschou SA, Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C. On type 1 diabetes mellitus pathogenesis. Endocrine connections. 2018 Jan 1; 7(1):R38-46. 7-Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. The Journal of the American Board of Family Medicine. 2009 Nov 1; 22(6):698-706. 8-Franca Gois PH, Wolley M, Ranganathan D, Seguro AC. Vitamin D deficiency in chronic kidney disease: Recent evidence and controversies. International journal of environmental research and public health. 2018Aug; 15(8):1773. 9-Haukka JK, Sandholm N, Forsblom C, Cobb JE, Groop PH, Ferrannini E. Metabolomic profile predicts development of microalbuminuria in individuals with type 1 diabetes. Scientific Reports. 2018 Sep 14; 8(1):1-0. 10- Prasad RM, Tikaria R. Microalbuminuria. [Updated 2022 Apr 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan- 11-MacIsaac RJ, Jerums G, Ekinci EI. Effects of glycaemic management on diabetic kidney disease. World journal of diabetes. 2017 May 15; 8(5):172. 12-- Razip, N.N.M., Gopalsamy, B., Abdul Mutalib, M.S., Chang, S.K., Abdullah, M.M.J.A., Azlan, A., Rejali, Z. and Khaza’ai, H.,. Correlation between levels of vitamins D3 and E in type 2 diabetes mellitus: A case-control study in Serdang, Selangor, Malaysia. Nutrients, 13(7), p.2288.2021 jul
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