The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient
DOI:
https://doi.org/10.32007/jfacmedbagdad.1979Keywords:
vitamin D3, , diabetes mellitus,, DMT1, , diabetic nephropathy (DNP)Abstract
Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's renoprotective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney disease.
Objective: to evaluate the role of vit D on renal function in patient with DMT1.
Patient and Method: The total number of study participants was 120, divided into three groups: Group A: Included 40 patients has DM with NP (stage1, stage 2, stage 3a), Group B included 40 patients had DM without NP, and group C included 40 healthy participants (control). Samples were taken from the Diabetic control clinic of Endocrinology and Diabetes center/Al-Kinde Hospital, Baghdad Teaching Hospital/ Medical City and Al-Shaheed Al- Sadder General Hospital during the period from October 2021 to March 2022.
Result: Statistically significant weak positive correlations were detected between vitamin D and GFR (r= 0.321, P= 0.001); while significant moderate negative correlation was seen between vitamin D and HbA1c (r= -0.494, P= 0.001) and weak negative correlation was seen with B. Urea (r= -0.2, P= 0.028). No statistically significant correlations detected between vitamin D and all of age, DM duration, and s. creatinine.
Conclusion: Our data suggest a correlation between reduced levels of vitamin D3 and diabetes nephropathy and it may be a potential predictor for both the occurrence and severity of diabetic nephropathy
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References
Saleh MM, Dhamad GD, Kamel LA. Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus. Journal of the Faculty of Medicine Baghdad. 2014;56(4):401-4.
https://doi.org/10.32007/med.1936/jfacmedbagdad.v56i4.13
-Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Research International. 2021 Jul 9;2021. https://doi.org/10.1155/2021/1497449
-Hamdi RA, Abdul-Qahar ZH, Kadhum EJ, Alsaeed FA. Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome. Journal of the Faculty of Medicine Baghdad. 2018 Sep 2;60(2):93-7.
https://doi.org/10.32007/19jfacmedbaghdad36.v60i2.12
-Mazanova A, Shymanskyi I, Lisakovska O, Hajiyeva L, Komisarenko Y, Veliky M. Effects of cholecalciferol on key components of vitamin D-endo/para/autocrine system in experimental type 1 diabetes. International Journal of Endocrinology. 2018 Feb 6;2018.
https://doi.org/10.1155/2018/2494016
-Galuška D, Pácal L, Kaňková K. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. Kidney and Blood Pressure Research. 2021;46(2):152-61. https://doi.org/10.1159/000514286
-Paschou SA, Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C. On type 1 diabetes mellitus pathogenesis. Endocrine connections. 2018 Jan 1;7(1):R38-46. https://doi.org/10.1530/EC-17-0347
-Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. The Journal of the American Board of Family Medicine. 2009 Nov 1;22(6):698-706. https://doi.org/10.3122/jabfm.2009.06.090037
-Franca Gois PH, Wolley M, Ranganathan D, Seguro AC. Vitamin D deficiency in chronic kidney disease: Recent evidence and controversies. International journal of environmental research and public health. 2018 Aug;15(8):1773.
https://doi.org/10.3390/ijerph15081773
-Haukka JK, Sandholm N, Forsblom C, Cobb JE, Groop PH, Ferrannini E. Metabolomic profile predicts development of microalbuminuria in individuals with type 1 diabetes. Scientific Reports. 2018 Sep 14;8(1):1-0.
https://doi.org/10.1038/s41598-018-32085-y
- Prasad RM, Tikaria R. Microalbuminuria. [Updated 2022 Apr 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-
-MacIsaac RJ, Jerums G, Ekinci EI. Effects of glycaemic management on diabetic kidney disease. World journal of diabetes. 2017 May 15;8(5):172. https://doi.org/10.4239/wjd.v8.i5.172
-- Razip, N.N.M., Gopalsamy, B., Abdul Mutalib, M.S., Chang, S.K., Abdullah, M.M.J.A., Azlan, A., Rejali, Z. and Khaza'ai, H.,. Correlation between levels of vitamins D3 and E in type 2 diabetes mellitus: A case-control study in Serdang, Selangor, Malaysia. Nutrients, 13(7), p.2288.2021 jul. https://doi.org/10.3390/nu13072288
-Rossing P, Frimodt-Møller M. Clinical features and natural course of diabetic nephropathy. In Diabetic Nephropathy 2019 (pp.21-32). Springer, Cham. https://doi.org/10.1007/978-3-319-93521-8_2
-Leslie RD, Evans-Molina C, Freund-Brown J, Buzzetti R, Dabelea D, Gillespie KM, Goland R, Jones AG, Kacher M, Phillips LS, Rolandsson O. Adult-onset type 1 diabetes: current understanding and challenges. Diabetes Care. 2021 Nov 1;44(11):2449-56.
https://doi.org/10.2337/dc21-0770
-Levey AS, Titan SM, Powe NR, Coresh J, Inker LA. Kidney disease, race, and GFR estimation. Clinical Journal of the American Society of Nephrology. 2020 Aug 7;15(8):1203-12. https://doi.org/10.2215/CJN.12791019
- Vahdat S. Vitamin D and kidney diseases: a narrative review. International journal of preventive medicine. 2020;11
https://doi.org/10.4103/ijpvm.IJPVM_54_19
- Márquez DF, Ruiz-Hurtado G, Segura J, Ruilope L. Microalbuminuria and cardiorenal risk: old and new evidence in different populations. F1000Research. 2019;8. https://doi.org/10.12688/f1000research.17212.1
-Lei M, Liu Z, Guo J. The emerging role of vitamin D and vitamin D receptor in diabetic nephropathy. BioMed research international. 2020 Jul 11;2020. https://doi.org/10.1155/2020/4137268
-Zhao WJ, Xia XY, Yin J. Relationship of serum vitamin D levels with diabetic microvascular complications in patients with type 2 diabetes mellitus. Chinese Medical Journal. 2021 Apr 5;134(07):814-20
https://doi.org/10.1097/CM9.0000000000001364
-Delrue C, Speeckaert R, Delanghe JR, Speeckaert MM. The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach. International Journal of Molecular Sciences. 2022 Jan 12;23(2):807. https://doi.org/10.3390/ijms23020807
-Perkins BA, Ficociello LH, Roshan B, Warram JH, Krolewski AS. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney international. 2010 Jan 1;77(1):57-64. https://doi.org/10.1038/ki.2009.399
-Moon S, Tsay JJ, Lampert H, Md Dom ZI, Kostic AD, Smiles A, Niewczas MA. Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration. Scientific reports. 2021 Apr 21;11(1):1-3.
https://doi.org/10.1038/s41598-021-87585-1
- De Boer IH, Sachs MC, Chonchol M, Himmelfarb J, Hoofnagle AN, Ix JH, Kremsdorf RA, Lin YS, Mehrotra R, Robinson-Cohen C, Siscovick DS. Estimated GFR and circulating 24, 25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials. American journal of kidney diseases. 2014 Aug 1;64(2):187-97.
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