Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus.

Sajid N. Abdualkader; Abdul- Wahab Al-Shaikly; Khalida M. Al-Mousawy; Mustafa Al-Ezzi; Maan G. Hasso; Zena E. Hassan

doi:10.32007/jfacmedbagdad.5141097

Authors

Sajid N. Abdualkader Teaching Laboratories, Medical city (Clinical Immunology.
Abdul- Wahab Al-Shaikly Dept. of Microbiology-Al-Kindi College of Medicine (Clinical Immunology)
Khalida M. Al-Mousawy Dept. of Microbiology-College of Medicine- University of Baghdad (Clinical Immunology)
Mustafa Al-Ezzi Rheumatology unit-Dept. of Medicine- University of Baghdad
Maan G. Hasso Teaching Laboratories, Medical city (Clinical Immunology.
Zena E. Hassan Dept. of Immunology, College of Medicine, Al-Yarmouk University.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5141097

Keywords:

Autoantibodies, Interleukin-4, Interleukin-6, systemic lupus erythematosus

Abstract

Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE
Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched, control subjects and studied for the presence of auto antibodies, plus IL-4 and IL-6 using Elisa method and immune fluorescent method (for ANA only)
Results: Data showed that IL-6 detectable levels were statistically significant in patients with positive anti ds-DNA, but not significant statistically in ANA positive patients although it was detected in 24 (70.6%) of positive ANA patients, while there was no statistically significant correlation between IL- 4 detectable level and autoantibodies production.
Conclusion: There is apparently a positive correlation between IL-6 and anti ds DNA production in lupus patients.