Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer: A follow up study

  • Zainab A. M. Ali Ibn Sena Teaching Hospital. Mosul.
  • Wasan K. Jasim Rozh Halat Emergency Hospital .Erbil.
  • Dilan Z.  Hussein Rozh Halat Emergency Hospital .Erbil.
  • Manwar     Abd.   Alnaqash Dept. of Surgery, College of Medicine/ Baghdad University
Keywords: Breast cancer, Tamoxifen, the lipid profile, premenopausal women.

Abstract

 Background: Breast cancer composed of several biologic subtypes that have response to hormonal therapy. Tamoxifen is  hormonal therapy  with tissue- pecific antagonistic or agonist effects, the latter being responsible for multiple  effects on lipid metabolism in women .

Objective: This study was designed to determine the impact of Tamoxifen on the serum lipid profile in breast cancer women. 

Patients and methods: Prospective observation cohort study conducted at Oncology Teaching Hospital, Medical city complx.starting from October 2015 to October 2016. A total number of 40 premenopausal women with breast cancer   were enrolled in this study according to inclusion criteria . Patients were followed for three months by the measurements TC, TG, HDL – cholesterol and BMI .

Results: At the end of third months of hormonal therapy, Tamoxifen showed a significant decrease in TG, VLDL (p< 0.001 for both).  On the other side HDL and BMI  showed significant increase over three months duration , (p = 0.001  and 0.006, respectively) .

Conclusion: Beneficial alterations of lipid profiles were seen in pre-menopausal breast cancer patients treated with Tamoxifen.                                                          

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Author Biographies

Zainab A. M. Ali, Ibn Sena Teaching Hospital. Mosul.

FIBMS CP

Wasan K. Jasim, Rozh Halat Emergency Hospital .Erbil.

FIBMS  CP

Dilan Z.  Hussein, Rozh Halat Emergency Hospital .Erbil.

  FIBMS CP

Manwar     Abd.   Alnaqash, Dept. of Surgery, College of Medicine/ Baghdad University

   DMRT MSc (Pathology)

 

Published
2018-12-31
How to Cite
1.
Ali Z, Jasim W, Hussein D, AlnaqashM  . Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer: A follow up study. JFacMedBagdad [Internet]. 31Dec.2018 [cited 26Sep.2020];60(3):141-4. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/602