Immunohistochemistry on cell blocks a method for pre-operative diagnosis of papillary thyroid carcinoma by FNAC

  • Hussain A. Aljebori Dept. of Pathology/ College of Medicine/University of Al-Mustansiriyah.
Keywords: Papillary thyroid carcinoma, FNAC, Cell blocks, IHC.

Abstract

Background: Papillary thyroid carcinoma (PTC) is the commonest thyroid cancer. Cases in category-
5a of Bethesda system (suspicious for papillary carcinoma) are treated by surgical lobectomy followed
by total thyroidectomy if histopathology confirms papillary carcinoma. In order to reduce surgical
procedures to one this was conducted.
Objectives: evaluation of role of immunohistochemistry in pre-operative diagnosis of papillary thyroid
carcinoma on cell blocks.
Materials and Method: Cell blocks were taken from cases labelled category-5a for histopathology and
immunohistochemistry using three markers (CK-19, Thyro-peroxidase, and BRAFv600E mutation).
Results: were highly sensitive, and specific. The use of more than markers increases sensitivity of the
procedure.
Conclusion: immunohistochemical stains on cell blocks is a reliable method for pre-operative diagnosis
of papillary thyroid carcinoma.

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Published
2018-09-02
How to Cite
1.
Aljebori H. Immunohistochemistry on cell blocks a method for pre-operative diagnosis of papillary thyroid carcinoma by FNAC. J Fac Med Bagdad [Internet]. 2Sep.2018 [cited 24Jan.2020];60(2):102-4. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/14