Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus

  • Madha M. Sheet Saleh Dept. of Medical Laboratories, College of Health and Medical Technology.
  • Ghuroob D. Dhamad Health directorate Baghdad Alrissafa/ Shaab Sector
  • Laith Abul-Ellah Kamel Clinical immunology consultant, Al-Karama Hospital.
Keywords: Diabetic nephropathy, interleukin-18, tumor necrotic factor-alpha.

Abstract

Background: Diabetic nephropathy (DN) represents the most common cause of end stage renal disease (ESRD) worldwide. Diabetic nephropathy occurs as a result of an interaction between hemodynamic and metabolic factors, however recent evidence shows an increase growing support for the notion that inflammation plays a key role in the pathogenesis of diabetic nephropathy.
Objectives: To speculate the role of IL-18 and TNF-α proinflammatory cytokines in the initiation and development of diabetic nephropathy in T1DM and T2DM.
Materials and methods: Eighty seven T1DM and T2DM patients with or without DN were enrolled. IL-18 and TNF-α cytokines were measured by solid phase immunosorbent assays.
Materials and methods: Eighty seven T1DM and T2DM patients with or without DN were enrolled. IL-18 and TNF-α cytokines were measured by solid phase immunosorbent assays.
Results: IL-18 had increased significantly in patients with DN compared to those without DN in T1DM and T2DM patients whereas TNF-α had exhibited a significant elevation among patients with DN compared to those without DN in T2DM but not T1DM.
Conclusion: IL-18 is suggested to play a crucial role in the initiation, development, and progression of DN in T1DM and T2DM patients whereas TNF-α is playing a similar role but only in T1DM patients with DN.

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Published
2015-01-04
How to Cite
1.
Sheet Saleh M, Dhamad G, Kamel L. Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus. JFacMedBagdad [Internet]. 4Jan.2015 [cited 11May2021];56(4):401-4. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/556