The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital

  • Sarmad M. Zeiny Dept. of microbiology, college of medicine, University of Baghdad.
Keywords: β-thalassemia major, PCR-SSO, HLA class II.

Abstract

Background: Thalassemia is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin.
Objective: Determine frequencies & association of HLA class II alleles (DRB1& DQB1) in Iraqi β-thalassemia major patients.
Patients: seventy unrelated randomly selected β-thalassemia major patients, and one hundred unrelated randomly selected healthy individuals, composed the control group.
Methods: low resolution PCR-SSO (Sequence Specific Oligonucleotide) technique was used for HLA typing.
Results: HLA DQB1*5 give significance importance as an etiological risk factor for β-thalassemia major; HLA DQB1*3 give significance importance as a preventive risk factor for β-thalassemia major.
Conclusion: The positive association of HLA DQB1*5 and DQB1*3 with β-thalassemia major may have the possibility that these antigens, or the genes encoding them, are closely linked with other possible susceptibility genes.

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Published
2016-01-03
How to Cite
1.
Zeiny S. The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital. JFacMedBagdad [Internet]. 3Jan.2016 [cited 11May2021];58(4):366-70. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/287