HLA Diversity in Iraqi Population: Molecular Typing

  • Ahmed A.H. Abbas Dept. of Microbiology, College of Medicine/ Al-Nahrain University.
Keywords: HLA; Genotyping; PCR.

Abstract

Background: Different populations show various human leukocyte antigens (HLA). Data of HLA distribution is important in field of vaccines, therapy, Anthropology and for future studies of disease association with HLA.
Objective: To highlight on frequency of HLA alleles in Iraqi population by using molecular technique.
Patients and methods: Two hundred individuals were genotyped for HLA class I and II alleles by polymerase chain reaction sequence-specific oligonucleotides (PCR-SSO).
Results: This study observed that the alleles with highest frequency were: [A*02(27.75%,A*01(10.75%,A*03(8%),B*51(17.75%),B*35(9%),B*07(6%),C*04(26.75%),C*07(20.25%),C6*0(9.75%),DRB1*02(17.5%,DRB1*07(17%),DRB1*04(14.75%)DQB1*01(25.5%),DQB1*03(21.75%),DQB1*02(19%)].
Conclusion: Current study give additional information about HLA distribution in Iraqi Arab society and could be provide standard control for future studies about HLA association with disease in Iraq.

Downloads

Download data is not yet available.
Published
2016-07-03
How to Cite
1.
Abbas A. HLA Diversity in Iraqi Population: Molecular Typing. JFacMedBagdad [Internet]. 3Jul.2016 [cited 6May2021];58(2):176-9. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/236