Study of ATPase and GTPase levels in Fibrotic Lung Disease with and without COVID-19 Vaccination

Authors

  • Raed M. Al-Azawee Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq. https://orcid.org/0009-0006-3778-0970
  • Zeinab M. Al-Rubaei Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad , Baghdad, Iraq. https://orcid.org/0000-0002-2742-3068

DOI:

https://doi.org/10.32007/jfacmedbagdad.6622272

Keywords:

ATPase;, GTPase;, , COVID-19 Vaccination; , Fibrotic Lung Disease.

Abstract

Background: In eukaryotic cells, the acidification of intracellular compartments is the responsibility of vacuolar H+ ATPase, a family of proton pumps, sometimes known as V-ATPases. Small GTPases are signaling molecules that regulate important cellular processes as well as subcellular activities making them essential players, particularly in a wide variety of coronavirus infection processes.

Objectives: The purpose of this research was to assess the levels of ATPase and GTPase in fibrotic lung disease patients who had received or had not received the COVID-19 vaccination, and then to compare these levels with those of the control group.

Methods: A total of 150 individuals participated in this study, divided into three groups. The first group was the control group (N=50). In the second group (N=50) patients with fibrotic lung disease () who did not get the COVID-19 vaccination. Fifty patients who had received the COVID-19 vaccination made up the third group ()(N=50). Enzyme-linked immunosorbent assay was the method that was used to determine the amounts of ATPase and GTPase. The P- P-value of 0.05 or less is considered statistically significant. ROC tests were examined for ATPase and GTPase.     

Results: The data analysis reported a significant rise in alkaline phosphatase, Alanine aminotransferase, and Aspartate-aminotransferase  () among the three groups. Both ATPase and GTPase levels were shown to have significantly increased in Groups 3 and 2 as compared to Group 1 levels. Moreover, a substantial rise was discovered in Group 3  in comparison to Group 2 which was detected.

Conclusion: ATPase and GTPase levels are increased in patients with fibrotic lung disease regardless of the COVID-19 vaccination state.  

 

 

 

 

 

 

 

 

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Author Biographies

  • Raed M. Al-Azawee, Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Baghdad, Iraq.

    University of Baghdad

  • Zeinab M. Al-Rubaei , Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad , Baghdad, Iraq.

    Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad , Baghdad, Iraq.

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ATPase; GTPase; COVID-19 Vaccination; Fibrotic Lung Disease.

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Published

01.07.2024

How to Cite

1.
Al-Azawee RM, Al-Rubaei ZM. Study of ATPase and GTPase levels in Fibrotic Lung Disease with and without COVID-19 Vaccination. J Fac Med Baghdad [Internet]. 2024 Jul. 1 [cited 2024 Dec. 13];66(2):135-40. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2272

Publication Dates

Received

2023-12-07

Revised

2024-03-20

Accepted

2024-04-08

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