Impact of Clinical Pharmacist Intervention on Chemotherapy Knowledge, Attitude, and Practice among Breast Cancer Women

Authors

DOI:

https://doi.org/10.32007/jfacmedbagdad.6612221

Keywords:

Attitude, Chemotherapy, Knowledge, Practice, Pharmaceutical care

Abstract

Background: Drug toxicity and chemotherapeutic side effects negatively impact breast cancer patients.

Objectives: To evaluate the effectiveness of pharmaceutical interventions in improving breast cancer patients' knowledge, attitude, and practice regarding breast cancer chemotherapy.

Patients and methods: A pre-post clinical pharmacist interventional study was conducted at the chemotherapy ward of AlHabbobi Hospital in AlNasiriyah City, located in the south of Iraq. The study involved fifty women with breast cancer who were provided with comprehensive pharmaceutical care and a self-compiled medication knowledge guide pamphlet. Two sessions were conducted for each patient; the first was conducted after the patient filled out a questionnaire at baseline and the second was conducted after 21 days, depending on the chemotherapy schedule. Each session lasted for approximately 45 minutes. Participants were requested to fill out the questionnaire at the end of the study.  Within the group,  a paired t-test was used to compare the changes before and after the invention.

Results: The clinical pharmacist’s intervention significantly increased breast cancer patients' knowledge, attitude, and practice regarding chemotherapy. After the intervention, there was a significant increase (P value < 0.05) in patients' answers to the knowledge domain accuracy. Many of the answers improved from 92% to 100% accuracy

Conclusion: The intervention of a clinical pharmacist is crucial in reducing complications and adverse effects associated with breast cancer chemotherapy

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Author Biographies

  • Karar H. Alkashaf , Oncology Center, AlHabbobi Hospital, Thi Qar Health Directorate, Thi Qar- Iraq

    Oncology Center, AlHabbobi Hospital, Thi Qar Health Directorate, Thi Qar- Iraq

  • Samer I. Mohammed, Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad-Iraq

    Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad-Iraq

References

Ahmed AAR. Awareness of breast cancer among university female students in Baghdad. AL-Kindy College Medical Journal [Internet]. 2019 Sep 11 [cited 2023 Sep 22];15(1):6–14. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/67

Al-Alwan NAS. The Actual Practice of Breast Self-Examination among Sample of Iraqi Patients with Breast Cancer. AL-Kindy College Medical Journal [Internet]. 2020 Jan 30 [cited 2023 Sep 22];15(2):28–34. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/157

Abdulwahid hiba mohammed. Comparison between Mammography and Breast Ultrasound in the Detection of Breast Cancer in Dense Breast Tissue among a Sample of Iraqi Women. J Fac Med Baghdad [Internet]. 2019 Jul 29 [cited 2023 Aug 31];61(1):25–9. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/889

Alwan NAS, Tawfeeq FN, Muallah FH. Breast Cancer Subtypes among Iraqi Patients: Identified By Their ER, PR and HER2 Status. J Fac Med Baghdad [Internet]. 2018 Jan 2 [cited 2023 Sep 22];59(4):303–7. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/69

Abood RA, Abdahmed KA, Mazyed SS. Epidemiology of Different Types of Cancers Reported in Basra, Iraq. Sultan Qaboos University Medical Journal [SQUMJ] [Internet]. 2020 Oct 5 [cited 2023 Sep 22];20(3):295. Available from: https://pubmed.ncbi.nlm.nih.gov/33110644/.

Shihab IK, H. Mohammed M. Synthesis, Characterization and Preliminary Anticancer Study of Novel 5-fluorouracil Conjugate with Pyrrolidine Dithiocarbamate as a Mutual Anticancer Prodrug. Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) [Internet]. 2019 Dec 21 [cited 2023 Sep 22]; 28(2):17–23. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/874.

Saberzadeh-Ardestani B, Khosravi B, Zebardast J, Sadighi S. Chemotherapy effect on daytime sleepiness and contributing factors in older adults with cancer. J Geriatr Oncol [Internet]. 2019 Jul 1 [cited 2023 Sep 22];10(4):632–6. Available from: https://pubmed.ncbi.nlm.nih.gov/30377061/.

Iqbal MJ, Mohammad Ishaq G, Assiri AA. Connecting Pharmacists and Other Health Care Providers (HCPs) towards Drug Therapy Optimization: A Pharmaceutical Care Approach. Int J Clin Pract [Internet]. 2023 [cited 2023 Sep 22];2023. Available from: https://pubmed.ncbi.nlm.nih.gov/36713950/.

Gu Y, Mu X, Zhang Y, Tang Y, Zhang T, Tang F. The Effect of Patients’ Psychological Contract with Pharmacists on Medication Adherence: A Qualitative Study. Patient Prefer Adherence [Internet]. 2023 [cited 2023 Sep 22];17:547–55. Available from: https://pubmed.ncbi.nlm.nih.gov/36896269/ .

Whitman A, Fitch E, Nightingale G. The role of oncology pharmacists and comprehensive medication reconciliation in informing treatment plans for older adults with cancer and downstream outcomes. Curr Opin Support Palliat Care [Internet]. 2023 Mar 1 [cited 2023 Sep 22]; 17(1):3–7. Available from: https://pubmed.ncbi.nlm.nih.gov/36695863/ .

Erdeljac H, Yager S, McClain M, Wall S, Presley C, Folefac E, et al. Pharmacist-Led Audits for Older Adults With Cancer Yield Significant Interventions. Innov Aging [Internet]. 2020 Dec 16 [cited 2023 Sep 22]; 4(Supplement_1):208–208. Available from: https://dx.doi.org/10.1093/geroni/igaa057.672.

Mohammed SI, Al-Shadedi MI, Kasim AA. Knowledge, Use and Recommendation of Iraqi Pharmacist Toward Complementary and Alternative Medicine. Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) [Internet]. 2020 Jun 21 [cited 2023 Sep 22]; 29(1):88–93. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/967 .

Mohammed SI, Dawood EB, Abaas IS. Perceptions and attitudes of community pharmacists towards patient counseling and continuing pharmacy education programs in Iraq. Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) [Internet]. 2019 Dec 22 [cited 2023 Sep 22];28(2):30–6. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/879 .

de Grégori J, Pistre P, Boutet M, Porcher L, Devaux M, Pernot C, et al. Clinical and economic impact of pharmacist interventions in an ambulatory hematology-oncology department. J Oncol Pharm Pract [Internet]. 2020 Jul 1 [cited 2023 Sep 22];26(5):1172–9. Available from: https://pubmed.ncbi.nlm.nih.gov/32299314/.

Faqeer N, Mustafa N, Abd Al-jalil N, Qur’an T. Impact of clinical pharmacists in an inpatient medical oncology service: A prospective study at a comprehensive cancer center in Jordan. J Oncol Pharm Pract [Internet]. 2021 Jun 1 [cited 2023 Sep 22];27(4):897–901. Available from: https://pubmed.ncbi.nlm.nih.gov/32703083/.

Lively A, Minard L V., Scott S, Deal H, Lambourne T, Giffin J. Exploring the perspectives of healthcare professionals in delivering optimal oncology medication education. PLoS One [Internet]. 2020 Feb 1 [cited 2023 Jun 18];15(2). Available from: https://pubmed.ncbi.nlm.nih.gov/32049970/.

National Cancer Institute. Chemotherapy and you. US Department of Health & Human Services | National Institutes of Health [Internet]. 2018;68. Available from: http://www.cancer.gov/cancertopics/coping/chemotherapy-and-you.

Dicato MA, Van Cutsem E. Side effects of medical cancer therapy: Prevention and treatment: Second edition. Side Effects of Medical Cancer Therapy: Prevention and Treatment: Second Edition. 2018 Jun 27;1–513. https://doi.org/10.1007/978-3-319-70253-7.

Marian M, Roberts S. Clinical Nutrition for Oncology Patients. Jones and Bartlett Publishers [Internet]. 2010 [cited 2023 Oct 5];1–243. Available from: https://www.jblearning.com/catalog.

Wang Y, Wu H, Xu F. Impact of Clinical Pharmacy Services on KAP and QOL in Cancer Patients: A Single-Center Experience. Biomed Res Int [Internet]. 2015 [cited 2023 Sep 22];2015:1–8. Available from: https://pubmed.ncbi.nlm.nih.gov/26697487/.

Heydarzadeh L, Alilu L, Habibzadeh H, Rasouii J. The Effect of Peer Education on Knowledge, Comprehension, and Knowledge Application of Patients Regarding Chemotherapy Complications. Iran J Nurs Midwifery Res [Internet]. 2019 Jan 1 [cited 2023 Sep 22];25(1):40–6. Available from: https://pubmed.ncbi.nlm.nih.gov/31956596/

Darling JO, Raheem F, Carter KC, Ledbetter E, Lowe JF, Lowe C. Evaluation of a Pharmacist Led Oral Chemotherapy Clinic: A Pilot Program in the Gastrointestinal Oncology Clinic at an Academic Medical Center. Pharmacy (Basel) [Internet]. 2020 Mar 20 [cited 2023 Sep 22]; 8(1):46. Available from: https://pubmed.ncbi.nlm.nih.gov/32244894/.

Mohammed SI, Sabry AT, Sabry DT. Assessment of Health Beliefs among Iraqi Breast Cancer Patients in Baghdad using either Tamoxifen or Trastuzumab. Iraqi Journal of Pharmaceutical Sciences (P-ISSN: 1683 - 3597, E-ISSN : 2521 - 3512) [Internet]. 2021 Dec 11 [cited 2023 Aug 31];30(2):113–21. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1311.

Daupin J, Perrin G, Lhermitte-Pastor C, Loustalot MC, Pernot S, Savoldelli V, et al. Pharmaceutical interventions to improve safety of chemotherapy-treated cancer patients: A cross-sectional study. J Oncol Pharm Pract [Internet]. 2019 Jul 1 [cited 2023 Sep 22];25(5):1195–203. Available from: https://pubmed.ncbi.nlm.nih.gov/30691354/

Al-Attar ZI. Irritable Bowel Syndrome: The Most Common Presentation, Severity Ranking and Therapeutic Regimens among Patients Attending Outpatient. AL-Kindy College Medical Journal [Internet]. 2020 Jul 24 [cited 2023 Sep 22]; 16(1):10–7. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/183

Wang Y, Wu H, Xu F. Impact of clinical pharmacy services on KAP and QOL in Cancer Patients: A single-center experience. Biomed Res Int. 2015;2015. https://doi.org/10.1155/2015/502431.

Colombo LRP, Aguiar PM, Lima TM, Storpirtis S. The effects of pharmacist interventions on adult outpatients with cancer: A systematic review. J Clin Pharm Ther [Internet]. 2017 Aug 1 [cited 2023 Sep 22];42(4):414–24. Available from: https://pubmed.ncbi.nlm.nih.gov/28556392/.

Al-Taie A, Izzettin F V., Sancar M, Köseoğlu A. Impact of clinical pharmacy recommendations and patient counselling program among patients with diabetes and cancer in outpatient oncology setting. Eur J Cancer Care (Engl) [Internet]. 2020 Sep 1 [cited 2023 Oct 10];29(5):e13261. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/ecc.13261.

Park D, Patel S, Yum K, Smith CB, Tsao CK, Kim S. Impact of Pharmacist-Led Patient Education in an Ambulatory Cancer Center: A Pilot Quality Improvement Project. J Pharm Pract [Internet]. 2022 Apr 1 [cited 2023 Oct 11];35(2):268–73. Available from: https://consensus.app/details/pharmacistled-counseling-sessions-shown-patients-park/24421f44ce1b5002932150ed644d0a98/.

Shrestha S, Shakya S, Khatiwada AP. An Urgent Necessity for Clinical Pharmacy Services in Cancer Care in Nepal. JCO Glob Oncol. 2020 Nov 17;(6):1392–3. https://doi.org/10.1200/GO.20.00434.

Walter C, Mellor JD, Rice C, Kirsa S, Ball D, Duffy M, et al. Impact of a specialist clinical cancer pharmacist at a multidisciplinary lung cancer clinic. Asia Pac J Clin Oncol [Internet]. 2016 Sep 1 [cited 2023 Jun 28];12(3):e367–74. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/ajco.12267 .

Jackson K, Letton C, Maldonado A, Bodiford A, Sion A, Hartwell R, et al. A pilot study to assess the pharmacy impact of implementing a chemotherapy-induced nausea or vomiting collaborative disease therapy management in the outpatient oncology clinics. Journal of Oncology Pharmacy Practice [Internet]. 2019 Jun 27 [cited 2023 Oct 31];25(4):847–54. Available from: https://doi.org/10.1177/1078155218765629 .

Lihara H, Ishihara M, Matsuura K, Kurahashi S, Takahashi T, Kawaguchi Y, et al. Pharmacists contribute to the improved efficiency of medical practices in the outpatient cancer chemotherapy clinic. J Eval Clin Pract [Internet]. 2012 Aug 18 [cited 2023 Jun 28]; 18(4):753–60. Available from: https://pubmed.ncbi.nlm.nih.gov/21414113/

Hansen EA, Pietkiewicz JM, Blum BL. Evaluation of the Feasibility and Utility of a Pharmacist-Centered Collaborative Drug Therapy Management Program for Oncology-Based Symptom Management. J Pharm Pract [Internet]. 2016 Jun 1 [cited 2023 Jun 28]; 29(3):206–11. Available from: https://pubmed.ncbi.nlm.nih.gov/25510586/.

Ribed A, Romero-Jiménez RM, Escudero-Vilaplana V, Iglesias-Peinado I, Herranz-Alonso A, Codina C, et al. Pharmaceutical care program for onco-hematologic outpatients: safety, efficiency and patient satisfaction. Int J Clin Pharm [Internet]. 2016 Apr 1 [cited 2023 Jun 28];38(2):280–8. Available from: https://pubmed.ncbi.nlm.nih.gov/26715547/.

Shawahna R, Awawdeh H. Pharmacists’ knowledge, attitudes, beliefs, and barriers toward breast cancer health promotion: a cross-sectional study in the Palestinian territories. BMC Health Serv Res [Internet]. 2021 Dec 1 [cited 2023 Sep 22];21(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33952277/ .

Chan CWH, Tai D, Kwong S, Chow KM, Chan DNS, Law BMH. The Effects of Pharmacological and Non-Pharmacological Interventions on Symptom Management and Quality of Life among Breast Cancer Survivors Undergoing Adjuvant Endocrine Therapy: A Systematic Review. Int J Environ Res Public Health [Internet]. 2020 Apr 2 [cited 2023 Sep 22];17(8). Available from: https://pubmed.ncbi.nlm.nih.gov/32344759/ .

Huang HP, Wen FH, Yang TY, Lin YC, Tsai JC, Shun SC, et al. The effect of a 12-week home-based walking program on reducing fatigue in women with breast cancer undergoing chemotherapy: A randomized controlled study. Int J Nurs Stud [Internet]. 2019 Nov 1 [cited 2023 Sep 22];99. Available from: https://pubmed.ncbi.nlm.nih.gov/31442785/.

Serrano D, Bonanni B, Brown K. Therapeutic cancer prevention: achievements and ongoing challenges - a focus on breast and colorectal cancer. Mol Oncol [Internet]. 2019 Mar 1 [cited 2023 Sep 22];13(3):579–90. Available from: https://pubmed.ncbi.nlm.nih.gov/30690875/.

Saad AH, Rabeea IS, Salih HN. Adherence and Beliefs to Adjuvant Hormonal Therapy in Patients with Breast Cancer: A Cross-Sectional Study (Conference Paper) #. Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) [Internet]. 2021 [cited 2023 Sep 22];30(Suppl.):31–9. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1530

Reitz LK, Schroeder J, Raick M, de Fragas Hinnig P, Vieira FGK, De Assis MAA, et al. Diet Quality Influences the Occurrence of Food Aversions in Women Undergoing Adjuvant Chemotherapy for Breast Cancer. Int J Environ Res Public Health [Internet]. 2022 Nov 1 [cited 2023 Sep 22];19(21). Available from: https://pubmed.ncbi.nlm.nih.gov/36360799/.

Fuente González CE, Chávez-Servín JL, De La Torre-Carbot K, Ronquillo González D, Aguilera Barreiro MDLÁ, Ojeda Navarro LR. Relationship between Emotional Eating, Consumption of Hyperpalatable Energy-Dense Foods, and Indicators of Nutritional Status: A Systematic Review. J Obes [Internet]. 2022 [cited 2023 Sep 22];2022. Available from: https://pubmed.ncbi.nlm.nih.gov/35634585/ .

I. Rasheed J, M. Abbas H. Implementation of a Clinical Pharmacy Training Program in Iraqi Teaching Hospitals : Review Article. Iraqi Journal of Pharmaceutical Sciences (P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) [Internet]. 2017 Mar 28 [cited 2023 Sep 7]; 21(1):1–5. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/433

Attitude, Chemotherapy, Knowledge, Practice, Pharmaceutical care

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Published

2024-04-01

How to Cite

1.
H. Alkashaf K, I. Mohammed S. Impact of Clinical Pharmacist Intervention on Chemotherapy Knowledge, Attitude, and Practice among Breast Cancer Women. JFacMedBagdad [Internet]. 2024 Apr. 1 [cited 2024 May 2];66(1):103-9. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2221

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