Correlation between Demographic Characteristic and Oxidized Low Density Lipoprotein (OxLDL-IgM and OxLDL-IgG) Antibodies levels in patients with Systemic Lupus Erythematosus Patients

Authors

DOI:

https://doi.org/10.32007/jfacmedbagdad.6612002

Keywords:

Immunoglobulins G; , Immunoglobulins M; , Oxidized Low-Density Lipoprotein antibody; , Obesity;, Systemic Lupus Erythematosus.

Abstract

Background: Systemic Lupus Erythematosus (SLE) may affect one or more organ systems; as time goes on, other manifestations may start to appear. Musculoskeletal, cutaneous, renal, and endocrine systems are all involved in SLE. The nervous system, hematological, vascular, pulmonary, gastrointestinal, and ocular imbalance of the immune response and the production of autoantibodies such as anti-oxidized Low-Density Lipoprotein LDL antibodies have a clear impact on the body’s organs and the development of complications of the disease.

Objectives: To assess the levels of anti-oxLDL (IgM-Abs) and anti-oxLDL (IgG-Abs) as biomarkers for disease activity in SLE patients and their relationship to demographic characteristics.

Patients and Methods: The study comprised 100 of SLE patients admitted to the Rheumatology Unit at Baghdad Teaching Hospital, age range (33.4 to 9.95) years, including 7 males and 93 females. An enzyme-linked immunosorbent Assay ELISA was used to measure the levels of serum oxLDL (IgM-Abs) and oxLDL (IgG-Abs).

Results:  The results of the present study showed that there was a significant difference between the levels of anti-oxLDL IgM antibodies(Abs) in SLE patients in obese and non-obese groups since the levels of anti-oxLDL-IgM Abs in obese patients were (3.14 µg/L) and non-obese patients were (5.13 µg/L) (P=0.005), while in SLE patients with Diabetes Mellitus (D.M.), the levels of anti-ox LDL-IgM Abs were (3.80 µg/L) and in SLE patients with no DM were (5.13 µg/L). Also, the results showed that there were no significant differences between levels of anti-oxLDL IgG Abs in obese patients with SLE (6.28 µg/L) and non-obese patients with SLE (10.25µg/L) P > 0.05.

Conclusion: There was found a significant difference between levels of anti-oxLDL IgM Abs in obese and non-obese in patients with SLE, and no significant differences between the levels of anti-oxLDL IgG Abs in the same groups of patients.

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Author Biographies

  • Nusaibah K. Al-Zubaidi, Department of Medical Microbiology, College of Medicine, University of Baghdad, Baghdad, Iraq

    Department of Medical Microbiology, College of Medicine, University of Baghdad, Baghdad, Iraq

  • Suha A. Al-Fakhar , Clinical Communicable Disease Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq

    Clinical Communicable Disease Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq

  • Mohammad H. Al-Osami, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq.

    Department of Medicine, College of Medicine, University of Baghdad

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Immunoglobulins G; Immunoglobulins M; Oxidized Low-Density Lipoprotein antibody; Obesity, Systemic Lupus Erythematosus,

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Published

2024-07-01

How to Cite

1.
K. Al-Zubaidi N, A. Al-Fakhar S, H. Al-Osami M. Correlation between Demographic Characteristic and Oxidized Low Density Lipoprotein (OxLDL-IgM and OxLDL-IgG) Antibodies levels in patients with Systemic Lupus Erythematosus Patients. J Fac Med Baghdad [Internet]. 2024 Jul. 1 [cited 2024 Jul. 13];66(2):171-7. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2002

Publication Dates

Received

2022-10-23

Revised

2022-11-01

Accepted

2024-03-25

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