Spontaneous Abortion and Failure of Human Cytotrophoblasts to adopt a vascular adhesion phenotype

Authors

  • Asmaa' Bauer Al-Obaidi Department of Medical Microbiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq
  • Alaa Gina Hussain Department of Pathology and Forensic Medicine, College of Medicine, Al Nahrain University, Baghdad, Iraq
  • Haider Ahmed Shamran Medical Research Center, College of Medicine, Al-Nahrain University, Baghdad, Iraq

DOI:

https://doi.org/10.32007/jfacmedbagdad.4841465

Keywords:

Abortion.. cytotrophoblasts, PECAM-1, VCAM-1.

Abstract

Background: Differentiating cytotrophoblasts transform their adhesion receptor phonotype so as to resemble the endothelial cells they replace a process that is required for normal placentation, and any defect in this adhesion phenotype switch might lead to pregnancy failure.
Patients and Methods: Curate samples of the materno-fetal interface were taken from 20 women with spontaneous first trimester abortion and 6 control women undergone elective termination of pregnancy in the first trimester. Immunohistochemistry analysis of paraffin embedded sections of these curate samples was performed using monoclonal antibodies for cytokeratin, PECAM-1 and VCAM-1.
Results: Cytokeratin showed positive immunostaing of the cytotrophoblasts lining the blood vessels, and PECAM-1 was positive in the cytotrophoblasts in only two cases who had elective
termination of their pregnancy, while VCAM-1 immunostaining of the cytotrophoblasts was positive in three cases that had elective termination of pregnancy and only
two cases that had spontaneous abortion.
Conclusion: Defective expression of endothelial cell adhesion molecules in human cytotrophoblasts might predispose to abnormal placentation, pregnancy failure and subsequent abortion.

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Published

02.07.2007

How to Cite

1.
Al-Obaidi AB, Hussain AG, Shamran HA. Spontaneous Abortion and Failure of Human Cytotrophoblasts to adopt a vascular adhesion phenotype. J Fac Med Baghdad [Internet]. 2007 Jul. 2 [cited 2024 Dec. 22];48(4):402-6. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1465

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