HLA Profile in Iraqi Rheumatic Valvulitis Patients

Ahmed A.A. Al-Hassan; Mohammed Al-Faham; Sana’a Al-Naseri; Emad Al-Mashat; Qassim Al-Douri; Ameera J. Al-Nnema; Salwa M. Shereef

doi:10.32007/jfacmedbagdad.4921387

Authors

Ahmed A.A. Al-Hassan Immunology , AL-Mussyaib Technical college.
Mohammed Al-Faham Microbiology , Medical College / University of Baghdad
Sana’a Al-Naseri Immunopathology / Medical College / University of Baghdad.
Emad Al-Mashat Department of Surgery/ Medical College / University of Baghdad.
Qassim Al-Douri Consultant cardioliologist/ Ibn Al-Betar Heart Hospital.
Ameera J. Al-Nnema Medico – Legal Institute.
Salwa M. Shereef Tissue Typing Center in AL-Karamah Teaching Hospital.

DOI:

https://doi.org/10.32007/jfacmedbagdad.4921387

Keywords:

HLA, rheumatic valvulitis

Abstract

Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region influence susceptibility to certain disease.
Objectives: This study was established to shed light on the possible association of HLA class I and II antigens with RV patients.
Patients and Methods: Lymphocytotoxicity assay for HLA for class I and II typing had been done for (100) Iraqi patients suffering from rheumatic valvulitis (RV), the control groups consisting of (75 healthy individuals and 35 non rheumatic heart disease (NRHD) patients ).
Results: The results showed a significant association of A33-Ags with these patients as compared with healthy and cardiac controls (P=0.005), (P=0.033) respectively. Another interesting finding was the low frequency of A1 in RV patients when compared with healthy control (p=0.002), suggesting that A1 allele may confer protective effect against this disease. In addition significant association between blood group B and RV was evident (p=0.04). An interesting observation was a strong association of blood group B and A33 among those patients (P<0.001).
Conclusion: The present results are consistent with hypothesis that susceptibility to RV is genetically linked and in turn may be associated mainly with A33 in Iraqi patients.