Increased Frequency of Complement C4 "Null" Alleles in Autoimmune Hepatitis

Eman S. AL-Obeidy; Khalida M. Mousawy; Raghad J H AL-Akayshi; Laith A. Kamil

doi:10.32007/jfacmedbagdad.5131131

Increased Frequency of Complement C4 "Null" Alleles in Autoimmune Hepatitis

Authors

Eman S. AL-Obeidy Dept. of virology, Medical laboratory, Medical city
Khalida M. Mousawy Dept. of Microbiology, Medical College/ University of Baghdad.
Raghad J H AL-Akayshi Gasteroentestinal and Hepatology Teaching Hospital.
Laith A. Kamil Dept. of immunology Al-Karama Teaching Hospital

DOI:

https://doi.org/10.32007/jfacmedbagdad.5131131

Keywords:

autoimmune hepatitis, HLA, C4A*Q0, Immunofixation test.

Abstract

Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region influence susceptibility to certain diseases.
Patients and methods: Immunofixation test is the method used to asses C4 polymorphism of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: An increased frequency of C4A*Q0 was observed for patients group versus control group with P-value (0.003).
Conclusions: This finding demonstrated that C4A*Q0 might play a role in AIH susceptibility.

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18-3-2009

Published

01.10.2009

Issue

Vol. 51 No. 3 (2009): Journal of the Faculty of Medicine Baghdad

Section

Articles

How to Cite

AL-Obeidy ES, Mousawy KM, AL-Akayshi RJH, Kamil LA. Increased Frequency of Complement C4 "Null" Alleles in Autoimmune Hepatitis. J Fac Med Baghdad [Internet]. 2009 Oct. 1 [cited 2024 Dec. 27];51(3):304-7. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1131