Causes &clinical presentation of hypotonia in children

Authors

  • Mahjoob N. AL-Naddawi Pediatric department, College of Medicine, Baghdad University
  • Russul F. Mussa Pediatric department, College of Medicine, Baghdad University
  • Khawla M. kamel Fatima Al- Zahra Maternity & children hospital

DOI:

https://doi.org/10.32007/jfacmedbagdad.5141078

Keywords:

Hypotonia, presentation, central, peripheral, onset.

Abstract

Background: Hypotonia is not a specific medical disorder, but a potential manifestation of many different diseases and disorders. The long-term effects of hypotonia on a child's development and later life depend primarily on the severity of the muscle weakness and the nature of the cause.
Patients &Methods: A prospective, cross sectional descriptive study in which 62 patients with hypotonia, age 3months to13 years, were evaluated in children welfare teaching hospital /Baghdad (a tertiary care center), over 4months Period (1st of January to 1st of May,2008 ) . Children were categorized into groups of central , peripheral& systemic hypotonia, and specific diagnosis of each of groups was made by clinical findings, neuroimaging, metabolic, muscular enzymes, Electromyography-Nerve conduction velocity, thyroid function tests, Serum Calicium&X- RAY of left wrist,& TORCH (Toxoplasmosis,others, rubella, CMV, herps simplex) assay in our medical teaching laboratories.
Results: The most common cause of hypotonia was central in 30 patients (48.4 %). (Four patient with unknown causes), the most common lesion was brain atrophy detected by CT scan examination in 23/30 (76.7%). Peripheral causes found in 14/58 (22.6%) which include myopathies in 7 patients (11.3%), anterior horn cell lesion in 7 patients (11.3%). Systemic causes were found in 14/58 (22.6%). Early Onset in 46/62 (74.2%), while late onset constituted 16/62 (25.8%).The most common mode of presentation is delayed mile stones found in 32 patients (51.6%).
Conclusions: The most common cause of hypotonia in children enrolled in the study is central lesion and commonly occurs in pre natal, natal & post natal periods. The most common finding is brain atrophy diagnosed by CT scan, while the most common presentation is delayed milestones, and most common type of weakness is proximal.

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Published

03.01.2010

How to Cite

1.
AL-Naddawi MN, Mussa RF, kamel KM. Causes &clinical presentation of hypotonia in children. J Fac Med Baghdad [Internet]. 2010 Jan. 3 [cited 2024 Nov. 21];51(4):348-52. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1078

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