Salivary aspartate amino transferase and alanine amino transferase of non-insulin-dependents (Type2) diabetic patients.

Abstract

Background: Diabetes mellitus (DM) is a world-wide chronic metabolic disorder affects relatively high percentage of population. A few information is available in diabetes on the salivary content of enzymes GOT (AST) and GPT (ALT).
Patients and methods: we studied 19 patients (NIDDM, type 2 diabetes mellitus aged 29-67 year). Colorimetric determination of salivary GPT and GOT activity was used.
Results: In the whole saliva of non-insulin-dependent (NIDDM, n=19) diabetic patients and from agecross- matched healthy subjects (n=19). Saliva concentrations of GOT (43.92=12.8U/L) in NIDDM patients were higherly significant (P< 0.001) than those observed in normal subjects (23.0± 8.84 U/L). GPT was higher in NIDDM than in normal subjects (15.63±7.25, 10.2±7.31U/L respectively) too.
Conclusion: Determination of cytosolic enzymes GPT&GOT in saliva may be useful for monitoring the diabetic involvement.