Increased Frequency of Complement C4 "Null" Alleles in Autoimmune Hepatitis

  • Eman S. AL-Obeidy Dept. of virology, Medical laboratory, Medical city
  • Khalida M. Mousawy Dept. of Microbiology, Medical College/ University of Baghdad.
  • Raghad J H AL-Akayshi Gasteroentestinal and Hepatology Teaching Hospital.
  • Laith A. Kamil Dept. of immunology Al-Karama Teaching Hospital
DOI: https://doi.org/10.32007/jfacmedbagdad.v3304-307%25
Keywords: autoimmune hepatitis, HLA, C4A*Q0, Immunofixation test.

Abstract

Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region influence susceptibility to certain diseases.
Patients and methods: Immunofixation test is the method used to asses C4 polymorphism of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: An increased frequency of C4A*Q0 was observed for patients group versus control group with P-value (0.003).
Conclusions: This finding demonstrated that C4A*Q0 might play a role in AIH susceptibility.

Downloads

Download data is not yet available.
Published
2009-10-01
How to Cite
1.
AL-Obeidy E, Mousawy K, AL-Akayshi R, Kamil L. Increased Frequency of Complement C4 "Null" Alleles in Autoimmune Hepatitis. J Fac Med Bagdad [Internet]. 1Oct.2009 [cited 21Nov.2019];51(3):304-7. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1131
Issue
Vol 51 No 3 (2009): Journal of the Faculty of Medicine Baghdad
Section
Articles

 For all articles published in Journal of the Faculty of Medicine Baghdad, copyright is retained by the authors. Articles are licensed under an open access Creative Commons CC BY NC 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. These conditions allow for maximum use and exposure of the work, while ensuring that the authors receive proper rights.