Human Cytomegalovirus Up-regulates Nuclear Factor-κB in Women with Spontaneous Abortion

المؤلفون

  • Asmaa’ Baqer Al-Obaidi Department of Medical Microbiology, College of Medicine, Al-Nahrain University.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5041236

الكلمات المفتاحية:

HCMV, NF-κB, abortion

الملخص

Background: Human cytomegalovirus (HCMV) infection during pregnancy causing serious problems through induction of viral genes that enhance the expression of different cellular factors ending in failure of pregnancy.
Patients and Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein, and in situ hybridization technique to detect nuclear factor-κB (NF- κB) mRNA.
Results: Only nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of NF-κB in HCMV positive cases as compared with HCMV negative and the control group (p = 0.001).
Conclusion: This study strengthen the possibility that HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the expression of the transcriptional factor; NF-κB.

التنزيلات

تنزيل البيانات ليس متاحًا بعد.

منشور

2009-01-04

كيفية الاقتباس

1.
Baqer Al-Obaidi A. Human Cytomegalovirus Up-regulates Nuclear Factor-κB in Women with Spontaneous Abortion. J Fac Med Baghdad [انترنت]. 4 يناير، 2009 [وثق 13 نوفمبر، 2024];50(4):484-7. موجود في: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1236

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