Lymphocyte subsets phenotype in patients with infectious mononucleosis
DOI:
https://doi.org/10.32007/jfacmedbagdad.5121219الكلمات المفتاحية:
Infectious mononucleosis, CD-Marker profile and EBV.الملخص
Background: Infectious mononucleosis (IM) is a lymphoproliferative disease caused primarily by the Epstein-Barr virus (EBV) infection. The initial viral infection by EBV occurs in B lymphocytes and is followed by an extensive proliferation of T lymphocytes. Previous studies on immunity to EBV (including IM) have mainly focused on activation of peripheral blood T cells, which are responsible for the lymphocytosis in blood during acute IM.
Patients and Methods: Indirect immunofluorescence technique analysis was performed to detect the percentage of CD3, CD4, CD8, CD19, and CD56 positive lymphocytes.
Results: Our results on the phenotype of T cells in samples from patients with infectious mononucleosis showed that there is a significant increase in percentage of CD8+ T-cells when compared with healthy group. In addition, increased in percentage of CD3 T-cells and moderately increase in CD56 (NK) cells. CD4 and CD19 percentage were significantly decrease in comparison with healthy control.
Conclusion: Acute infectious mononucleosis is characterized by a marked increase in the percentage of CD3 and CD8 T- cells with a slight increase in CD56 percentage. A marked decrease in CD19 percentage and CD4/CD8 ratio was noticed.
التنزيلات
التنزيلات
منشور
إصدار
القسم
الرخصة
Permit others to copy and distribute the manuscript; to extract, revise, and create another derivative
works of or from the manuscript (e.g., a translation); to incorporate the manuscript into a
collective work; and to text or data mine the article, even for commercial purposes, provided that
the author(s) is/are credited; the article's modifications should not harm the author's honor or
reputation; and the article should not be altered in a way that would cause the author to lose them
reputation. The Creative Commons Attribution 4.0 International License (CC BY 4.0) has more
information.
كيفية الاقتباس
Creative Commons Attribution 4.0 International license..
