Treatment of Forty Adult Patients with Hodgkin Disease; Baghdad Teaching Hospital Experience

  • Mohammed S. Abbas Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Alaadin S. Naji Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Ahmed A. AL - Saffar Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Mazin A. Shubbar Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Bassam F. Matti Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Adil Siwan Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Ammar F. Majeed Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
  • Ali M. Jawad Hematology Unit/Baghdad Teaching Hospital/Baghdad/Iraq.
Keywords: Hodgkin disease, ABVD, Survival.

Abstract

Background: Hodgkin disease was the first cancer in which the curative potential of combination chemotherapy was demonstrated. The affected patients are often young and there is a great potential for adding years of productive life by giving curative therapy even when the disease is advanced.
Objective: to describe the experience of the hematology unit,Baghdad Teaching Hospital, in the management of 40 adult patients with Hodgkin disease.
Patients and Methods: a retrospective cohort study of forty adult Iraqi patients with Hodgkin disease between 2005 and 2013 in the hematology unit. Patients were treated initially with 6-8 cycles of ABVD chemotherapy protocol (doxorubicine+ bleomycin+ vinblastin+ dacarbazine) , nine patients received additional involved field radiotherapy for residual masses or bulky disease. Overall survival and progression free survivals were estimated using Kaplan Meier survival plot.
Results: The mean age was 28.6±12.88 years with females forming 61.5% of patients, mean duration of follow up was 27.9± 20.6 months. Staging showed that 55% and 27.5% had stage II and III respectively. B symptoms were found in 72.5% patients , bulky disease in 42.5% patients. Complete Response+ Complete Response undetermined was seen in 85% of cases. First Relapse occurred in 14%, and death in 7.5% of the patients. The 8 year overall survival and progression free survival were 82% and 50% respectively while the mean overall survival and progression free survival times were 84.7 and 59.9 months respectively.
Conclusion: The results of the treatment of adult patients with Hodgkin disease in our unit is rather comparable to the results from other studies.

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Published
2015-07-01
How to Cite
1.
Abbas M, Naji A, AL - Saffar A, Shubbar M, Matti B, Siwan A, Majeed A, Jawad A. Treatment of Forty Adult Patients with Hodgkin Disease; Baghdad Teaching Hospital Experience. JFacMedBagdad [Internet]. 1Jul.2015 [cited 11May2021];57(2):129-33. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/341