Platelet Parameters in Nonthrombocytopenic Preeclampsia: A Case-Control Study
DOI:
https://doi.org/10.32007/jfacmedbagdad.2084Keywords:
preeclampsia, platelet parameters, thrombocytopenia, platelet count, mean platelet volume, platelet distribution widthAbstract
Background: Preeclampsia is a pregnancy-specific, multisystem condition characterized by the onset of de novo hypertension and proteinuria occurring in previously normotensive women after the twentieth week of pregnancy. Pregnancy is associated with a physiological adaptation that leads to changes in the hematological system including platelet parameters.
Objectives: Is to compare platelet count, and platelet indices, namely mean platelet volume platelet distribution width and platelet count to mean platelet volume MPV ratio in preeclamptic patients with normal pregnant women.
Patients & methods: A case-control study was carried out in the obstetrics and gynecology department at Al-Khansaa Maternity and Childhood Teaching Hospital, Mosul, Iraq over a period extending from February 2020 to the end of December 2020. A sample of 120 pregnant women participated in the study fulfilling inclusion criteria. Sixty of them were diagnosed with preeclampsia PE (30 pregnant women with mild PE and 30 pregnant women with severe PE) and sixty healthy pregnant women as the control group. Platelet count, mean platelet volume, and platelet distribution width (PDW) were measured and statistical analysis by mini tab program was done for all collected data.
Results: A significant linear correlation between mean platelet volume (MPV) and platelet distribution width (PDW) with mean arterial pressure in the Preeclampsia group with p-value of (0.025 and 0.001) respectively and a significant inverse correlation between the platelet count and mean arterial pressure with a p-value of (<0.001) was observed.
Conclusion: Platelet parameters are cost-effective, easily measurable, and practical markers that can be used for the monitoring of preeclampsia. Mean platelet volume (MPV) and platelet distribution width (PDW) have a significant linear correlation with mean arterial pressure in severe preeclampsia and can be used as a biomarker for the severity of preeclampsia in high-risk pregnant women.
Received: Mar, 2022
Accepted: July, 2023
Published: Jan.2024
Downloads
References
AL-Maini EH, Ali SI. The correlation between serum levels of soluble platelet-selectin in preeclampsia with & without intrauterine growth retardation versus normal pregnancy. Journal of the Faculty of Medicine Baghdad. 2017 Apr 2;59(1):36-41. https://doi.org/10.32007/jfacmedbagdad.591156
American College of Obstetricians and Gynecologists. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' task force on hypertension in pregnancy. Obstetrics and gynecology, 2013 Nov; 122(5):1122-31.
Payne B, Magee LA, von Dadelszen P. Assessment, surveillance and prognosis in pre-eclampsia. Best practice & research Clinical obstetrics & gynaecology, 2011 Aug 1; 25(4):449-62. https://doi.org/10.1016/j.bpobgyn.2011.02.003
Edmonds K. Hypertensive Disorders. In: Dewhurst's Textbook of Obstetrics & Gynaecology. Ninth edition. UK: John Wiley & Sons Ltd. 2018 Nov 12:73-84.
Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: A systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013 Sep 1; 170(1):1-7. https://doi.org/10.1016/j.ejogrb.2013.05.005
Abass AE, Abdalla R, Omer I, Ahmed S, Khalid A, Elzein H. Evaluation of platelets count and indices in preeclampsia compared to normal pregnancies. IOSR Journal of Dental and Medical Sciences, 2016 Jul; 1(15):5-8. https://doi.org/10.9790/0853-150750508
Kaur S, Khan S, Nigam A. Hematological profile and pregnancy: a review. International Journal of Advances in Medicine, 2014 Aug; 1(2):68-70. https://doi.org/10.5455/2349-3933.ijam20140804
Mondal B, Paul DL, Sultana T, Rahman Q, Ahmed S, Fatema K et al. Assessment of platelet count and platelet indices in preeclampsia and eclampsia. The American Journal of Innovative Research and Applied Sciences, 2015; 1(3):80-4.
Asif N, Hassan K. Thrombocytopenia in pregnancy. Hematology & Transfusion International Journal, 2017; 5(5):1-4. https://doi.org/10.15406/htij.2017.05.00133
Bain BJ, Bates I, Laffan MA. Investigation of haemostasis. In: Dacie and Lewis 46 Practical Haematology. Twelfth edition. London: E-Book: Expert Consult: Online and Print. Elsevier Health Sciences. 2016 Aug 11: 336-409.
Jarjees SB. Evaluation of platelet count and mean platelet volume in normal and preeclamptic pregnant women. Iraq: Baghdad/college of medicine, 2011: 5. Dissertation for fellowship of the Arab Board for Medical Specialization in Obstetrics and Gynaecology.
Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia, 2010 Jan; 14(1):28.
Doğru HY, Yücel N, Pelit FÇ, Bolat G. The importance and evaluation of mean platelet volume on the severity of preeclampsia. Perinatal Journal, 2011; 19(3):108- 113.
https://doi.org/10.2399/prn.11.0193002
Tzur T, Sheiner E. Is there an association between platelet count during the first trimester and preeclampsia or other obstetric complications later in pregnancy?. Hypertension in pregnancy Taylor & Francis online, 2013 Feb 1; 32(1):74-82. https://doi.org/10.3109/10641955.2012.704109
Wang F, Meng Z, Li S, Zhang Y, Wu H. Platelet distribution width levels can be a predictor in the diagnosis of persistent organ failure in acute pancreatitis. Gastroenterology research and practice, 2017 Dec 27:2017. https://doi.org/10.1155/2017/8374215
Boshnak N, Boshnaq M, Elgohary H. Evaluation of platelet indices and red cell distribution width as new biomarkers for the diagnosis of acute appendicitis. Journal of Investigative Surgery. 2018 Mar 4;31(2):121-9.
https://doi.org/10.1080/08941939.2017.1284964
Tzur I, Barchel D, Izhakian S, Swarka M, Garach-Jehoshua O, Krutkina E, Plotnikov G, Gorelik O. Platelet distribution width: a novel prognostic marker in an internal medicine ward. Journal of Community Hospital Internal Medicine Perspectives. 2019 Nov 2;9(6):464-70. https://doi.org/10.1080/20009666.2019.1688095
Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D et al. Mean platelet volume in patients with prehypertension and hypertension. Clinical hemorheology and microcirculation, 2010 Jan 1; 45(1):67-72. https://doi.org/10.3233/CH-2010-1327
Thanoon AM, Jalal SD. Thrombocytopenia in Iraqi Pregnant Women. Journal of the Faculty of Medicine Baghdad. 2011 Jul 3;53(2):171-4. https://doi.org/10.32007/jfacmedbagdad.532864
NICE guideline criteria foe preeclampsia diagnosis/2020. https://action-on-pre-eclampsia.org.uk/wp-content/uploads/2020/01/NICE_guidance_on-Pre-eclampsia_VB2020.pdf
Stekkinger E, Zandstra M, Peeters LL, Spaanderman ME. Early-onset preeclampsia and the prevalence of postpartum metabolic syndrome. Obstetrics & Gynecology, 2009 Nov 1; 114(5):1076-84. https://doi.org/10.1097/AOG.0b013e3181b7b242
Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ER et al. preeclampsia and hypertensive disorder. In: Obstetrics: Normal and Problem Pregnancies. Seventh edition. London: E-book. Elsevier Health Sciences. 2016 Mar 18: 661-705.
A. Jagroop, I. Clatworthy, J. Lewin, DP Mikhailidis I. Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets, 2000 Jan 1; 11(1):28-32. https://doi.org/10.1080/09537100075760
Doğan K, Guraslan H, Senturk MB, Helvacioglu C, İdil S, Ekin M. Can platelet count and platelet indices predict the risk and the prognosis of preeclampsia?. Hypertension in pregnancy, 2015 Oct 2; 34(4):434-42. https://doi.org/10.3109/10641955.2015.1060244
AlSheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vascular health and risk management, 2016; 12:477. https://doi.org/10.2147/VHRM.S120944
Üstün YE, Dogan K, Türkçüoglu I, Üstün Y, Meydanl MM, Kafkasl A. Evaluation of hemoglobin and platelet levels in mild, moderate and severe preeclampsia. Perinatal Journal, 2007; 15(3): 93-8.
Vijaya C, Lekha MB, Shetty A, Geethamani V. Evaluation of platelet counts and platelet indices and their significant role in preeclampsia and eclampsia. Journal of Evolution of Medical and Dental Sciences, 2014 Mar 24; 3(12):3216-20. https://doi.org/10.14260/jemds/2014/2269
Annam V, Srinivasa K, Yatnatti SK, Med SD. Evaluation of platelet indices and platelet counts and their significance in preeclampsia and eclampsia. International Journal of Biological & Medical Research, 2011 Jan 31; 2(1):425-8.
Dhakre R, Nandmer GK, Sapkal R. Correlation of platelet indices with severity of preeclampsia: a prospective study from central India. International Journal Reprod Contracept Obstet Gynecol, 2018; 7(4):1416-20. https://doi.org/10.18203/2320-1770.ijrcog20181327
Nooh AM, Abdeldayem HM. Changes in platelet indices during pregnancy as potential markers for prediction of preeclampsia development. Open Journal of Obstetrics and Gynecology, 2015; 5(12):703. https://doi.org/10.4236/ojog.2015.512099
Dundar O, Yoruk P, Tutuncu L, Akyol Erikci A, Muhcu M, Ergur AR et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of preeclampsia. Prenatal Diagnosis: Affiliation With the International Society for Prenatal Diagnosis, 2008 Nov; 28(11):1052-6.
https://doi.org/10.1002/pd.2126
. Reddy SG, Prasad CS. Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases. Journal of laboratory physicians, 2019 Jul; 11(3):186. https://doi.org/10.4103/JLP.JLP_161_18
Ünlü BS, Acay A, Köken GG, Yıldız Y, Telciler E, Pektaş MK et al. The Role of Mean Platelet Volume in Preeclampsia. Journal of Turgut Ozal Medical Center, 2014 Sep 1; 21(3).
Ceyhan T, Beyan C, Başer İ, Kaptan K, Güngör S, Ifran A. The effect of preeclampsia on complete blood count, platelet count and mean platelet volume. Annals of hematology, 2006 May; 85(5):320-2. https://doi.org/10.1007/s00277-006-0091-7
Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2014 Apr 1; 175:107-11.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Hanan Dhannoon Nayyef, Ahmed Jasim Alhusaynei
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Permit others to copy and distribute the manuscript; to extract, revise, and create another derivative
works of or from the manuscript (e.g., a translation); to incorporate the manuscript into a
collective work; and to text or data mine the article, even for commercial purposes, provided that
the author(s) is/are credited; the article's modifications should not harm the author's honor or
reputation; and the article should not be altered in a way that would cause the author to lose them
reputation. The Creative Commons Attribution 4.0 International License (CC BY 4.0) has more
information.
How to Cite
Creative Commons Attribution 4.0 International license..
