The Effect of Chronic liver diseases on homocysteine and vitamin B12 in patients serum

Essam F. Al-Jumaily; Faiha'a M. Khaleel; Anis Al-Rawi

doi:10.32007/jfacmedbagdad.5141093

Authors

Essam F. Al-Jumaily Dept. of Genetic Engineering and Biotechnology Institute, Baghdad University
Faiha'a M. Khaleel Chemistry Dept. College of Science for Women, Baghdad University
Anis Al-Rawi Chemistry Dept. College of Science for Women, Baghdad University

DOI:

https://doi.org/10.32007/jfacmedbagdad.5141093

Keywords:

chronic liver disease, homocysteine, vitamin B12.

Abstract

Background: Homocysteine (Hcy) is a sulfur containing amino acid that is formed as an intermediary in methionine metabolism. Raised plasma homocysteine levels, which may contribute
to the increased risk of chronic liver disease.
Patients and Methods: Sixty two patients with chronic liver disease and 26 healthy individuals were included as normal controls for the study. The HPLC system was used for the determination of Hcy and vitamin B12.
Results: A highly significant Hcy concentrations were noted in all patients with cirrhosis, chronic hepatitis or liver mass. There was a trendency towards higher Hcy concentrations in more advanced stages of liver disease. The study showed that the concentrations of total Hcy were significantly higher in the patients than in the normal control group, irrespective of the age or gender. Mean serum concentration of vitamin B12 were significantly increased in cirrhotic patients and those with liver cancer compared to the control subjects and chronic hepatitis symptomatic patients.
Conclusion: The serum levels of both homocystein (Hcy) and vit. B12 were significantly increased in cirrhotic patients and those with liver cancer compared to chronic hepatitis
symptomatic patients.