Serum Interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthritis.

  • Anwar F. Al-Tai Dept. of Chemistry / College of Education for Pure Sciences / Baghdad University
Keywords: Rheumatoid arthritis (RA), Interleukin 35 (IL-35), High sensitivity C- reactive protein (hs CRP), Calcium (Ca), alkaline phosphatase (ALP).

Abstract

Background: Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis.

Patients and method: Serum of (55 Females) of newly diagnosed RA and 23 healthy Females were used to estimate their interlukine levels.Objective: To evaluate interlukine 35 (IL-35) in Iraqi females with newly diagnosed
RA and to assess its contribution in the disease process.

Results: Females of RA showed a significant increase in the levels of interleukine 35(IL-35) and in the levels of High Sensitivity C-Reactive Protein (hs CRP). While there were no significant changes in the level of alkaline phosphatase (ALP) and calcium (Ca). The correlation between IL-35 and each of hs CRP, ALP and Ca (-ve) were non-significant (r = -0.066, -0.04271 and -0.103) respectively.

Conclusion : This is the first study to show the elevation of serum levels of IL-35 in Iraqi female patients with newly diagnosed RA which indicates that IL- 35 may be a good biomarker for early RA.

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Published
2014-10-01
How to Cite
1.
Al-Tai A. Serum Interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthritis. JFacMedBagdad [Internet]. 1Oct.2014 [cited 15Aug.2020];56(3):322-4. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/523