Epstein-Barr Virus Antibodies in Rheumatoid Arthritis Iraqi patients

Authors

  • Aida R. Al-Derzi Dept. of Microbiology & Immunology/Collage of Medicine/University of Baghdad
  • Muhammad M. Alani Dept. of Microbiology & Immunology/Collage of Medicine/University of Baghdad
  • Hayfaa S. AL-Hadithi Dept. of Microbiology & Immunology/Collage of Medicine/University of Baghdad

DOI:

https://doi.org/10.32007/jfacmedbagdad.554585

Keywords:

Rheumatoid arthritis, Epstein-Barr virus, EBV-IgG, EBV-IgM, ELISA

Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. Many cases are believed to result from an interaction between genetic factors and environmental exposures. Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis.

Objective: To study the association between EBV antibodies and RA.

Patients and methods: This prospective study was carried out in the period between March 2013 and May 2013. The study involved 30 patients diagnosed with RA attending rheumatology outpatient's clinic Baghdad  medical city teaching hospital and 30 apparently healthy individuals as a control group. Serum samples were collected to investigate the level of EBV-IgG and IgM  by using ELISA technique.

Results: This study showed that 70% of control group had positive EBV-IgG while only 6 out of 30 had positive EBV-IgM. The mean values of EBV-IgG were significantly higher among RA patients (0.542 IU/ml) in comparison  with that in control group(0.269 IU/ml). Also mean value of serum EBV-IgM (0.723 IU/ml) were significantly higher than that in healthy individuals(0.354 IU/ml)

Conclusions: The serum levels of EBV-IgG and IgM were significantly higher in RA patients in contrast with those in healthy individuals

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Published

02.01.2014

How to Cite

1.
Al-Derzi AR, Alani MM, AL-Hadithi HS. Epstein-Barr Virus Antibodies in Rheumatoid Arthritis Iraqi patients. J Fac Med Baghdad [Internet]. 2014 Jan. 2 [cited 2024 Nov. 13];55(4):358-61. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/585

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