Development of Anti-bodies against Infliximab in Iraqi Patients with Rheumatoid Arthritis.

  • Mohammed A. Al-Karkhi Dept. of Microbiology &Immunology,college of medicine, University of Baghdad.
  • Muhammed M. Al-Ani Dept. of Microbiology &Immunology,college of medicine, University of Baghdad.
  • Nizar A. Jassim Reumatology Unit, Deparment of Medicine, College of Medicine, University of Baghdad.
Keywords: rheumatoid arthritis, infliximab, anti-infliximab antibodies. Original

Abstract

Background: Rheumatoid arthritis is a common chronic and destructive autoimmune arthropathy .Treatment with infliximab gives great improvement to a large numbers of patients with RA ,however, in some patients after prolonged treatment infliximab can induce anti-infliximab antibodies formation and result to loss of infliximab efficacy and active persistent disease.
Objective: to investigate the frequency of anti-infliximab antibodies in Iraqi patients with rheumatoid arthritis.
Patients and methods: fifty Iraqi RA patients(36 females and 14 males) compared with 50 control( 25 healthy control and 25 case control (patients with RA on other treatment) ) were included in this study from begging of March 2014 till end of September 2014.All patients were diagnosed by full history, complete clinical examination and laboratory test. Anti-infliximab antibodies were meatured using enzymelinked immunosorbent assay in serum of Iraqi patients with RA treated with infliximab more than 3 months
duration.
Results: Antibodies to infliximab were detected in 35(70%) Iraqi RA patients , while the patients without detectable antibodies against infliximab were 15(30%),also there were no anti-infliximab antibodies in the control groups.
Conclusion: In this study, nearly three quarter of the Iraqi RA patients treated with infliximab developed anti-infliximab antibodies.

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Published
2015-10-01
How to Cite
1.
Al-Karkhi M, Al-Ani M, Jassim N. Development of Anti-bodies against Infliximab in Iraqi Patients with Rheumatoid Arthritis. JFacMedBagdad [Internet]. 1Oct.2015 [cited 11May2021];57(3):241-3. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/372