Association of Neuregulin-4 levels and body mass index with hyperandrogenism in Polycystic Ovary Syndrome patients
DOI:
https://doi.org/10.32007/jfacmedbagdad.2140Keywords:
Neuregulin 4; BMI; Polycystic Ovary Syndrome; Free testosteroneAbstract
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disease that affects approximately 15% of women of childbearing age worldwide. It is one of the causes of infertility and is characterized by hirsutism, acne, persistent or interrupted anovulation, and hyperandrogenemia. Neuregulin-4 (NRG-4) is an adipokine hormone from the protein neuregulin family. Its level is greater in PCOS than in control women, and Neuregulin-4 is linked to body fat percentage and liver fat, as well as insulin resistance (IR).
Objectives: To estimate the serum NRG-4 levels in women diagnosed with (PCOS), to compare it with, non-PCOS healthy control and to explore the effect of hyperandrogenism on the obtained result.
Patients and Methods: A case-control study was conducted in the Gynecology and the Infertility Clinics in Kut - Zahraa Hospital, Medical City, from September to December 2022. The study included 120 women aged (18-42) years, 60 of whom were diagnosed with polycystic ovaries, and the other 60 were in the control group.
Results: Women with PCOS had a significantly higher NRG-4, LH, LH/FSH ratio, testosterone, free testosterone, and Dehydroepiandrosterone sulfate (DHEA-S) than the control groups. In this study, NRG-4 was significantly higher in obese and overweight PCOS women than in normal-weight women.Conclusion: The mean serum NGR-4 concentration is significantly increased in women with PCOS and could be a part of metabolic syndrome. NGR-4 levels were associated with obesity, hyperandrogenism (testosterone, free testosterone, and DHAES) and may have a role in the development of PCOS.
Received: May,, 2022
Accepted: Oct, 2023
Published: Jan.2024
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References
- Nori W, Hussein ZA and Hamdan MNA. 2023. The Reliability Of Serum Neuregulin-4 As A Marker Of Polycystic Ovarian Syndrome With Respect To Adiposity Parameters. Clinical And Experimental Obstetrics and Gynecology, 50, 89. DOI: 10.31083/j.ceog5004089
https://doi.org/10.31083/j.ceog5004089
- Alawad ZM. 2018. Level Of Follicular Fluid Vitamin D And Embryo Quality In A Sample Of Iraqi Women Undergoing Ivf. J Fac Med Baghdad 2018; Vol.60, No.4. DOI: https://doi.org/10.32007/jfacmedbagdad.604758
- Hamdi RA, Abas HN and Alsaeed FAA. 2019. Role Of Adropin In Women With Polycystic Ovary Syndrome. Scopus Ijphrd Cıtatıon Score, 10, 291. https://doi.org/10.5958/0976-5506.2019.02535.X
- Fadhil NM. 2022. Evaluation Of Serum Podocalyxin In Iraqi Women With Polycystic Ovary Syndrome. J Fac Med Baghdad, Vol.64, No. 4276-279. DOI: https://doi.org/10.32007/jfacmedbagdad.6441983
- Abdurrahman S, Ruslin R, Hasanah AN, Ifaya M. and Mustarichie R. 2023. Anti-Alopecia Activity of Coumarin Derivatives Isolated from Merremia peltata Leaves and Computational Study of Their Binding to Androgen Receptors Using Molecular Docking and Molecular Dynamic Simulation. Pharmaceuticals, 16, 669. https://doi.org/10.3390/ph16050669.
- Yesiladali M, Yazici MG, Attar E and Kelestimur F. 2022. Differentiating Polycystic Ovary Syndrome From Adrenal Disorders. Diagnostics, 12(9), 2045; https://doi.org/10.3390/diagnostics12092045
- Aburawi SM, Treesh SA, El Jaafari HA, El Ghedamsi MT 2021. Effect Of Vitamin E On Polycystic Ovary Syndrome Induced By Dehydroepiandrosterone In Female Albino Mice: Histological Study. Malaysian Journal Of Pharmaceutical Sciences, 19, 111-130. https://doi.org/10.21315/mjps2021.19.2.8
- Jasim AH, Al-Naddawi AM and Fibog C. 2022. Association Between Serum Fructose Level And Insulin Resistance In Women With Polycystic Ovary Syndrome: The Effect Of Obesity. JFac Med Baghdad; Vol.64, No . 2. DOI: https://doi.org/10.32007/jfacmedbagdad.6421926 .
- Liberale L and Montecucco F. 2020. Adipocytokines And Cardiovascular Diseases: Putative Role Of Neuregulin-4. Wiley Online Library. Vol 50, Issue8. https://doi.org/10.1111/eci.13306
- Dresselhaus EC and Meffert MK. 2019. Cellular Specificity Of Nf-Κb Function In The Nervous System. Frontiers In Immunology, 10, 1043. https://doi.org/10.3389/fimmu.2019.01043.
- Tutunchi H, Ostadrahimi A, Hosseinzadeh‐Attar MJ, Miryan M, Mobasseri M and Ebrahimi‐Mameghani M. 2020. A Systematic Review Of The Association Of Neuregulin-4, A Brown Fat-Enriched Secreted Factor, With Obesity And Related Metabolic Disturbances. Obesity Reviews, 21, E12952. https://doi.org/10.1111/obr.12952 .
- Kumar N and Agarwal H. 2022. Early Clinical, Biochemical And Radiological Features In Obese And Non-Obese Young Women With Polycystic Ovarian Syndrome: A Comparative Study. Horm Metab Res 2022; 54(09): 620-624 https://doi.org/10.1055/a-1880-1264
- Temur M, Calan M, Akşit M, Yılmaz Ö, Çift T, Akselim B, et al. 2017. Increased Serum Neuregulin-4 Levels In Women With Polycystic Ovary Syndrome: A Case-Control Study. Ginekologia Polska, 88, 517-522. https://doi.org/10.5603/GP.a2017.0095
- Mokou M, Yang S, Zhan B, Geng S, Li K, Yang M, et al. 2020. Elevated Circulating Fetuin-B Levels Are Associated With Insulin Resistance And Reduced By Glp-1ra In Newly Diagnosed Pcos Women. Hindawi Mediators of Inflammation Volume 2020, Article ID 2483435, 12 pages https://doi.org/10.1155/2020/2483435
- Al-Dahy LB, Almusawi YK and Ballur AFH. 2022. Assessment Of Neuregulin4 Function In Patients With Polycystic Ovary Syndrome Disorder. Journal Of Pharmaceutical Negative Results, 13, 676-678. DOI: https://doi.org/10.47750/pnr.2022.13.04.090
- Livadas S, Anagnostis P, Bosdou JK, Bantouna D and Paparodis R. 2022. Polycystic Ovary Syndrome And Type 2 Diabetes Mellitus: A State-Of-The-Art Review. World Journal Of Diabetes, 13, 5. https://doi.org/10.4239/wjd.v13.i1.5
- Acharya M and Mishra S. 2022. Women With Polycystic Ovary Syndrome Have Different Levels Of Abdominal Fat Distribution, Insulin Resistance, And Cardiovascular Risk Profiles. European Journal Of Molecular and Clinical Medicine. https://doi.2515-8260,9(3)3199-3203/
- Nitin K and Nataraj R. 2020. Hormones Of Hpg-Axis And Their Active Role During Chronic Stress And Pcos Induction: A Review. International Journal of Basic and Applied Sciences, Vol. 11. No.1. DOI: https://doi-ds.org/doilink/10.2020-51948721/
- Cutolo M, and Straub RH. (2020). Sex steroids and autoimmune rheumatic diseases: state of the art. Nature Reviews Rheumatology, 16(11), 628-644. DOIhttps://doi.org/10.1038/s41584-020-0503-4 https://doi.org/10.1038/s41584-020-0503-4
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