Association of Neuregulin-4 Levels and Body Mass Index with Hyperandrogenism in Polycystic Ovary Syndrome Patients
DOI:
https://doi.org/10.32007/jfacmedbagdad.2140Keywords:
BMI, Free testosterone, Neuregulin-4, Polycystic Ovary SyndromeAbstract
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disease that affects approximately 15% of women of childbearing age worldwide. It is one of the causes of infertility and is characterized by hirsutism, acne, persistent or interrupted anovulation, and hyperandrogenemia. Neuregulin-4 (NRG-4) is an adipokine hormone from the protein neuregulin family. Its level is greater in PCOS than in control women, and Neuregulin-4 is linked to body fat percentage and liver fat, as well as insulin resistance (IR).
Objectives: To estimate the serum NRG-4 levels in women diagnosed with (PCOS), to compare it with non-PCOS healthy control, and to explore the effect of hyperandrogenism on the obtained result.
Methods: A case-control study was conducted in the Gynaecology and Infertility Clinics in Kut-AlZahraa Hospital, Medical City, from September to December 2022. The study included 120 women aged 18-42 years, 60 of whom were diagnosed with polycystic ovaries, and the other 60 were in the control group.
Results: Women with PCOS had a significantly higher NRG-4, LH, LH/FSH ratio, testosterone, free testosterone, and dehydroepiandrosterone sulfate (DHEA-S) than the control groups. In this study, NRG-4 was significantly higher in obese and overweight PCOS women than in normal-weight women.
Conclusion: The mean serum NGR-4 concentration is significantly increased in women with PCOS and could be a part of metabolic syndrome. NGR-4 levels were associated with obesity and hyperandrogenism (testosterone, free testosterone, and DHAES) and may have a role in the development of PCOS.
Received: May, 2023
Revised: Sept. 2023
Accepted: Oct, 2023
Published: Jan. 2024
Downloads
References
1. Nori W, Hussein ZA, Hamdan MN. The Reliability of Serum Neuregulin-4 as a Marker of Polycystic Ovarian Syndrome with Respect to Adiposity Parameters. Clinical and Experimental Obstetrics & Gynecology. 2023 Apr 23;50(4):89. https://doi.org/10.31083/j.ceog5004089.
2. Alawad ZM. Level of follicular fluid vitamin D and embryo quality in a sample of Iraqi women undergoing IVF. Journal of the Faculty of Medicine Baghdad. 2018;60(4):215-21. https://doi.org/10.32007/jfacmedbagdad.604758.
3. Hamdi RA, Abas HN, Alsaeed FA. Role of adropin in women with polycystic ovary syndrome. Scopus Ijphrd Cıtatıon Score. 2019 Sep; 10(9):291. https://doi.org/10.5958/0976-5506.2019.02535.X
4. Fadhil NM. Evaluation of Serum Podocalyxin In Iraqi Women With Polycystic Ovary Syndrome. J Fac Med Baghdad, 2022; 64,(4):276-279. https://doi.org/10.32007/jfacmedbagdad.6441983.
5. Abdurrahman S, Ruslin R, Hasanah AN, Ifaya M, Mustarichie R. Anti-alopecia activity of coumarin derivatives isolated from Merremia peltata leaves and computational study of their binding to androgen receptors using molecular docking and molecular dynamic simulation. Pharmaceuticals. 2023 Apr 28;16(5):669. https://doi.org/10.3390/ph16050669.
6. Yesiladali M, Yazici MG, Attar E, Kelestimur F. Differentiating polycystic ovary syndrome from adrenal disorders. Diagnostics. 2022 Aug 24;12(9):2045. https://doi.org/10.3390/diagnostics12092045.
7. Aburawi SM, Treesh SA, El Jaafari HA, El Ghedamsi MT, Nafati NA, Benmahmoud OA, Almajry M, Shebani N. Effect of vitamin E on polycystic ovary syndrome induced by dehydroepiandrosterone in female albino mice: histological study. MJPS. 2021 Jul 1;19(2):111-30. https://doi.org/10.21315/mjps2021.19.2.8.
8. Jasim AH, Salih. BO, Al-Naddawi AM, FIBoG CA. Association between serum fructose level and insulin resistance in women with polycystic ovary syndrome: The effect of obesity. JFacMed Baghdad. 2022 Jul 24;64(2):91-5. https://doi.org/10.32007/jfacmedbagdad.6421926.
9. Liberale L, Montecucco F. Adipocytokines and cardiovascular diseases: Putative role of Neuregulin 4. European Journal of Clinical Investigation. 2020 Aug 1;50(8). https://doi.org/10.1111/eci.13306.
10. Dresselhaus EC, Meffert MK. Cellular specificity of NF-κB function in the nervous system. Frontiers in immunology. 2019 May 9;10:1043. https://doi.org/10.3389/fimmu.2019.01043.
11. Tutunchi H, Ostadrahimi A, Hosseinzadeh‐Attar MJ, Miryan M, Mobasseri M, Ebrahimi‐Mameghani M. A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances. OBR. 2020 Feb; 21(2): e12952. https://doi.org/10.1111/obr.12952.
12. Kumar N, Agarwal H. Early clinical, biochemical and radiological features in obese and non-obese young women with polycystic ovarian syndrome: a comparative study. Hormone and Metabolic Research. 2022 Sep;54(09):620-4. https://doi.org/10.1055/a-1880-1264
13. Temur M, Calan M, Akşit M, Yılmaz Ö, Çift T, Akselim B, Çakmak BD, Üstünyurt E. Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: a case-control study. Ginekologia Polska. 2017;88(10):517-22. https://doi.org/10.5603/GP.a2017.0095.
14. Mokou M, Yang S, Zhan B, Geng S, Li K, Yang M, Yang G, Deng W, Liu H, Liu D, Zhu Z. Elevated Circulating Fetuin‐B Levels Are Associated with Insulin Resistance and Reduced by GLP‐1RA in Newly Diagnosed PCOS Women. Mediators of Inflammation. 2020;2020(1):2483435.12. https://doi.org/10.1155/2020/2483435
15. Al-Dahy LB, Almusawi YK, Ballur AF. Assessment of Neuregulin4 function in patients with polycystic ovary syndrome disorder. JPNR. 2022;13(4):676-8. https://doi.org/10.47750/pnr.2022.13.04.090
16. Livadas S, Anagnostis P, Bosdou JK, Bantouna D, Paparodis R. Polycystic ovary syndrome and type 2 diabetes mellitus: A state-of-the-art review. WJD. 2022 Jan 1;13(1):5.https://doi.org/10.4239/wjd.v13.i1.5
17. Acharya M, Mishra S. Women With Polycystic Ovary Syndrome Have Different Levels Of Abdominal Fat Distribution, Insulin Resistance, And Cardiovascular Risk Profiles. EJMCM. https://doi. 2515-8260, 9 (3) 3199-3203. 2022. https://doi.2515-8260,9(3)3199-3203/
18. Nitin K, Nataraj R. Hormones of HPG-axis and their active role during chronic stress and PCOS Induction: a review. International Journal of Basic and Applied Sciences. 2020;11(1). https://doi-ds.org/doilink/10.2020-51948721.
19. Cutolo M, Straub RH. Sex steroids and autoimmune rheumatic diseases: state of the art. Nature Reviews Rheumatology. 2020 Nov;16(11):628-44. https://doi.org/10.1038/s41584-020-0503-4.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Mustafa M. Ghalib, Manal K. Rasheed & Afraa M. Al-Naddawi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons Attribution 4.0 International license..
