The Possible Role of Helicobacter pylori Infection in Hashimoto’s Thyroiditis
Keywords:Hashimoto’s thyroiditis, H. pylori, Anti-TPO.
Background: Autoimmune thyroiditis is one of autoimmune thyroid diseases. The cause of Hashimoto’s thyroiditis is not clearly identified; however, both genetic and environmental are suggested to play a role in pathogenesis of the disease. Helicobacter pylori (H pylori) is one of the possible causative agents.
Objectives: The aim of this study is to look for the association of H. pylori infection with Hashimoto’s thyroiditis.
Patients and Methods: a case-control study involved patients with Hashimoto’s thyroiditis (n=100) and control group (hyperthyroidism n=50, healthy persons n=50), the study groups were subjected to serological investigation of anti- H. pyloriIgG antibodies, anti-thyroid peroxidase antibody, and anti-thyroglobulin antibody(anti-TG Ab) using ELISA technique; besides, demographic data were collected from study
Results: Eighty two percent of Hashimoto’s thyroiditis patients were females; 57% of Hashimoto’s thyroiditis patients were positive for anti- H. pyloriIgG antibodies while the positive result was detected in only 22% of control group and the results were statistically significant (p <0.05). The strength and direction
of the relationship between the concentrations of anti-HP IgGAbs and anti-TPO antibodies in Hashimoto’s thyroiditis group revealed positive correlation (r = 0.6241).
Conclusion: the infection with H. pylori is one of the possible predisposing factors to etiology Hashimoto’s thyroiditis. The association between H. pylori infection and other genetic and environmental factors that are related to Hashimoto’s thyroiditis should be studied in depth.
How to Cite
For all articles published in Journal of the Faculty of Medicine Baghdad, copyright is retained by the authors. Articles are licensed under an open access Creative Commons CC BY NC 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. These conditions allow for maximum use and exposure of the work, while ensuring that the authors receive proper rights.