Adenosine Deaminase (ADA) in Rheumatoid Arthritis in patients (RA)

Authors

  • Huda Th. Al-Marsomi Department of Microbiology, College of Medicine, Al-Nahrin University.

DOI:

https://doi.org/10.32007/jfacmedbagdad.5121211

Keywords:

RA, ADA, IR.

Abstract

Background: Rheumatoid Arthritis (RA) is heterogenous syndrome. Because the diversity of disease processes and formation of complex lymphoid microstructures that indicate the multiple T cell activation pathways are involved .affected patients have major abnormalities in the T cell pool with clonally expanded CD4  + T cell that lose expression of the CD28null molecule and lack the ability for profiliration. Adenosine deaminase (ADA) is an indicator of the proliferation and differenation of lymphocyte, in particularly the T cell subcells.
Patients and Methods: Total ADA levels were measured in the sera of RA patients and healthy group according to Giusti (1981).
Results: The mean value of ADA was lower in patients with RA than control group with no significant differences.
Conclusion: the lower value of ADA (which involved in the proliferation of lymphocyte) in RA patients may results from the predominance of CD4
+ T cells in the peripheral blood

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Published

01.07.2009

How to Cite

1.
Al-Marsomi HT. Adenosine Deaminase (ADA) in Rheumatoid Arthritis in patients (RA). J Fac Med Baghdad [Internet]. 2009 Jul. 1 [cited 2024 Nov. 14];51(2):198-9. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1211

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