Proinflammatory cytokines profile in patients with Rheumatoid arthritis

Authors

  • Shahlaa M. Saleh Department of biotechnology/ college of science/ Al-Nahrain University
  • Jabbar R. Zangor Department of Microbiology/ college of Medicine/ Baghdad University

DOI:

https://doi.org/10.32007/jfacmedbagdad.5111174

Keywords:

Rheumatoid arthritis, TNF- , IL-1 and GM-CSF.

Abstract

Background:
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. It is a disabling and painful inflammatory condition, which can lead to substantial loss of mobility due to pain and joint destruction. RA is a systemic disease, often affecting extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and muscles. 
Patients and Methods: Enzyme immunoassay for Determination of human TNF- , IL-1 and GM-CSF in serumsamples from50 patients with a diagnosis of rheumatoid arthritis
Results: of cytokines showed a significant increase in TNF-alpha, IL-1 beta and GM-CSF in patients with rheumatoid arthritis (70.98 12.08) pg/ml,(238.6 116.4)pg/ml and (96.1 12.08)pg/ml respectively. When compared with the control group (7.0 3.09)pg/ml, (15.4 3.8)pg/ml and (6.8 3.03)pg/ml respectively.
Conclusion: Increased serum levels of proinflammatory cytokine such as TNF- , IL-1 and GM-CSF probably play important role in driving inflammatory process and promoting joint destruction in rheumatoid arthritis. Regulation of these cytokines is a crucial importance in the RA disease showing pleiotropic actions and many different targets.

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Published

01.04.2009

How to Cite

1.
Saleh SM, Zangor JR. Proinflammatory cytokines profile in patients with Rheumatoid arthritis. J Fac Med Baghdad [Internet]. 2009 Apr. 1 [cited 2024 Dec. 29];51(1):57-9. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1174

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