Cadmium Chloride (CdCl2)-Induced Apoptosis in Liver of Mice

  • Khalid Hamdan Gathwan College of Dentistry, dept. of basic science.
Keywords: Cadmium, mice, metal analysis, apoptosis.

Abstract

Background: Cadmium (Cd) is an industrial and environmental pollutant that affect adversely a number of organs in humans and other mammals.
Objectives: To study the effect of cadmium on liver of mice.
Material and Methods: Male Balb/c mice weighing 30-32 gm, 60 days old, were treated intraperitoneally (ip) with (1-10mg/kg body wt. /CdCl2). The body weight, liver weight, histological examination of liver, SEM, metal analysis along with DNA ladder for apoptosis.
Results: Cadmium induced both a time, and dose dependent increase in apoptotic, severity of necrosis. Liver weight, body weight decreased with increase of dose, while metal content was increased by increase of dose.
Conclusion: It has been concluded that cadmium caused necrotic effect on liver and apoptotic as well as decreased body weight and liver weight.

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Published
2006-10-01
How to Cite
1.
Gathwan K. Cadmium Chloride (CdCl2)-Induced Apoptosis in Liver of Mice. J Fac Med Bagdad [Internet]. 1Oct.2006 [cited 22Sep.2019];48(3):309-12. Available from: http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1507