The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient

Nadia A.  Mijbel; Shafa J. Ibrahim

doi:10.32007/jfacmedbagdad.1979

Authors

Nadia A. Mijbel Dept. of Biochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq. https://orcid.org/0009-0009-0820-620X
Shafa J. Ibrahim Dept. of Bochemistry, College of Medicine, University of Baghdad, Baghdad, Iraq.. https://orcid.org/0009-0005-4167-6335

DOI:

https://doi.org/10.32007/jfacmedbagdad.1979

Keywords:

vitamin D3, , diabetes mellitus,, DMT1, , diabetic nephropathy (DNP)

Abstract

Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's renoprotective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney disease.

Objective: to evaluate the role of vit D on renal function in patient with DMT1.

Patient and Method: The total number of study participants was 120, divided into three groups: Group A: Included 40 patients has DM with NP (stage1, stage 2, stage 3a), Group B included 40 patients had DM without NP, and group C included 40 healthy participants (control). Samples were taken from the Diabetic control clinic of Endocrinology and Diabetes center/Al-Kinde Hospital, Baghdad Teaching Hospital/ Medical City and Al-Shaheed Al- Sadder General Hospital during the period from October 2021 to March 2022.

Result: Statistically significant weak positive correlations were detected between vitamin D and GFR (r= 0.321, P= 0.001); while significant moderate negative correlation was seen between vitamin D and HbA1c (r= -0.494, P= 0.001) and weak negative correlation was seen with B. Urea (r= -0.2, P= 0.028). No statistically significant correlations detected between vitamin D and all of age, DM duration, and s. creatinine.

Conclusion: Our data suggest a correlation between reduced levels of vitamin D3 and diabetes nephropathy and it may be a potential predictor for both the occurrence and severity of diabetic nephropathy

Downloads

Download data is not yet available.

References

Saleh MM, Dhamad GD, Kamel LA. Inflammatory markers mediated diabetic nephropathy in patients with type 1 and type 2 diabetes mellitus. Journal of the Faculty of Medicine Baghdad. 2014;56(4):401-4.

https://doi.org/10.32007/med.1936/jfacmedbagdad.v56i4.13

-Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Research International. 2021 Jul 9;2021. https://doi.org/10.1155/2021/1497449

-Hamdi RA, Abdul-Qahar ZH, Kadhum EJ, Alsaeed FA. Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome. Journal of the Faculty of Medicine Baghdad. 2018 Sep 2;60(2):93-7.

https://doi.org/10.32007/19jfacmedbaghdad36.v60i2.12

-Mazanova A, Shymanskyi I, Lisakovska O, Hajiyeva L, Komisarenko Y, Veliky M. Effects of cholecalciferol on key components of vitamin D-endo/para/autocrine system in experimental type 1 diabetes. International Journal of Endocrinology. 2018 Feb 6;2018.

https://doi.org/10.1155/2018/2494016

-Galuška D, Pácal L, Kaňková K. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. Kidney and Blood Pressure Research. 2021;46(2):152-61. https://doi.org/10.1159/000514286

-Paschou SA, Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C. On type 1 diabetes mellitus pathogenesis. Endocrine connections. 2018 Jan 1;7(1):R38-46. https://doi.org/10.1530/EC-17-0347

-Kulie T, Groff A, Redmer J, Hounshell J, Schrager S. Vitamin D: an evidence-based review. The Journal of the American Board of Family Medicine. 2009 Nov 1;22(6):698-706. https://doi.org/10.3122/jabfm.2009.06.090037

-Franca Gois PH, Wolley M, Ranganathan D, Seguro AC. Vitamin D deficiency in chronic kidney disease: Recent evidence and controversies. International journal of environmental research and public health. 2018 Aug;15(8):1773.

https://doi.org/10.3390/ijerph15081773

-Haukka JK, Sandholm N, Forsblom C, Cobb JE, Groop PH, Ferrannini E. Metabolomic profile predicts development of microalbuminuria in individuals with type 1 diabetes. Scientific Reports. 2018 Sep 14;8(1):1-0.

https://doi.org/10.1038/s41598-018-32085-y

- Prasad RM, Tikaria R. Microalbuminuria. [Updated 2022 Apr 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-

-MacIsaac RJ, Jerums G, Ekinci EI. Effects of glycaemic management on diabetic kidney disease. World journal of diabetes. 2017 May 15;8(5):172. https://doi.org/10.4239/wjd.v8.i5.172

-- Razip, N.N.M., Gopalsamy, B., Abdul Mutalib, M.S., Chang, S.K., Abdullah, M.M.J.A., Azlan, A., Rejali, Z. and Khaza'ai, H.,. Correlation between levels of vitamins D3 and E in type 2 diabetes mellitus: A case-control study in Serdang, Selangor, Malaysia. Nutrients, 13(7), p.2288.2021 jul. https://doi.org/10.3390/nu13072288

-Rossing P, Frimodt-Møller M. Clinical features and natural course of diabetic nephropathy. In Diabetic Nephropathy 2019 (pp.21-32). Springer, Cham. https://doi.org/10.1007/978-3-319-93521-8_2

-Leslie RD, Evans-Molina C, Freund-Brown J, Buzzetti R, Dabelea D, Gillespie KM, Goland R, Jones AG, Kacher M, Phillips LS, Rolandsson O. Adult-onset type 1 diabetes: current understanding and challenges. Diabetes Care. 2021 Nov 1;44(11):2449-56.

https://doi.org/10.2337/dc21-0770

-Levey AS, Titan SM, Powe NR, Coresh J, Inker LA. Kidney disease, race, and GFR estimation. Clinical Journal of the American Society of Nephrology. 2020 Aug 7;15(8):1203-12. https://doi.org/10.2215/CJN.12791019

- Vahdat S. Vitamin D and kidney diseases: a narrative review. International journal of preventive medicine. 2020;11

https://doi.org/10.4103/ijpvm.IJPVM_54_19

- Márquez DF, Ruiz-Hurtado G, Segura J, Ruilope L. Microalbuminuria and cardiorenal risk: old and new evidence in different populations. F1000Research. 2019;8. https://doi.org/10.12688/f1000research.17212.1

-Lei M, Liu Z, Guo J. The emerging role of vitamin D and vitamin D receptor in diabetic nephropathy. BioMed research international. 2020 Jul 11;2020. https://doi.org/10.1155/2020/4137268

-Zhao WJ, Xia XY, Yin J. Relationship of serum vitamin D levels with diabetic microvascular complications in patients with type 2 diabetes mellitus. Chinese Medical Journal. 2021 Apr 5;134(07):814-20

https://doi.org/10.1097/CM9.0000000000001364

-Delrue C, Speeckaert R, Delanghe JR, Speeckaert MM. The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach. International Journal of Molecular Sciences. 2022 Jan 12;23(2):807. https://doi.org/10.3390/ijms23020807

-Perkins BA, Ficociello LH, Roshan B, Warram JH, Krolewski AS. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney international. 2010 Jan 1;77(1):57-64. https://doi.org/10.1038/ki.2009.399

-Moon S, Tsay JJ, Lampert H, Md Dom ZI, Kostic AD, Smiles A, Niewczas MA. Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration. Scientific reports. 2021 Apr 21;11(1):1-3.

https://doi.org/10.1038/s41598-021-87585-1

- De Boer IH, Sachs MC, Chonchol M, Himmelfarb J, Hoofnagle AN, Ix JH, Kremsdorf RA, Lin YS, Mehrotra R, Robinson-Cohen C, Siscovick DS. Estimated GFR and circulating 24, 25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials. American journal of kidney diseases. 2014 Aug 1;64(2):187-97.

https://doi.org/10.1053/j.ajkd.2014.02.015