تأثير جرعة الميتفورمين والإلتزام بالعلاج على التحكم في نسبة السكر في الدم والسمنة وعلامات مخاطر القلب والأوعية الدموية لدى المرضى العراقيين الذين يعانون من داء السكري النوع الثاني
DOI:
https://doi.org/10.32007/jfacmedbagdad.6441939الكلمات المفتاحية:
Glycemic control، Metformin dose، Treatment adherence، T2DM، Visceral adiposityالملخص
الخلفية: قد تساهم العديد من العوامل، بما في ذلك جرعات الميتفورمين والإلتزام بالعلاج في إختلافات كبيرة في التحكم في نسبة السكر في الدم وعلامات السمنة لمرضى السكري من النوع الثاني.
الهدف: تهدف هذه الدراسة إلى تحديد تأثير جرعة الميتفورمين والإلتزام بالعلاج على التحكم في نسبة السكر في الدم وعلامات السمنة لدى المرضى العراقيين الذين يعانون من هذا المرض.
المنهجية: بين سبتمبر 2021 ومارس 2022، شملت دراسة مقطعية في مركز السكري والغدد الصماء - بغداد 153 مريضا من مرضى T2DM الذين تزيد مدة مرضهم عن عام واحد. وأجريت فحوص سريرية وبدنية قبل التسجيل. قمنا بقياس المتغيرات الأنثروبومترية مثل مؤشر كتلة الجسم، ونسبة الخصر إلى الورك، ومؤشر السمنة الحشوية وغيرها من المؤشرات البديلة. قمنا بتقييم الهيموغلوبين السكري، اللبتين، البروتين التفاعلي، الكوليسترول الكلي، HDL-c ، والدهون الثلاثية في مصل الدم.
النتائج: لم تحسن زيادة جرعات الميتفورمين المعايير المستهدفة. يؤثر الإلتزام بالعلاج بشكل كبير على نسبة السكر في الدم، ومستوى HbA1c ، وعلامات السمنة. وفي الوقت نفسه، فإن زيادة جرعات الميتفورمين لا ترتبط بالتغيرات في مقاومة الأنسولين وعلامات خطر الإصابة بأمراض القلب والأوعية الدموية.
الإستنتاج: بغض النظر عن زيادة جرعة الميتفورمين، يؤثر الإلتزام بالعلاج على التحكم في نسبة السكر في الدم، والسمنة الحشوية، ومعايير مخاطر الأمراض القلبية الوعائية. لم تكن زيادة جرعة الميتفورمين مقترنة بمقاومة الأنسولين ومحتويات الدهون في الجسم.
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الحقوق الفكرية (c) 2022 Zainab Abdulrahman, Mohammed Qasim Alatrakji, Ahmed Abood Al-Maliky, Khalid Ibrahim Hussein, Saad Abdulrahman Hussain
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