Evaluation of Serum Apelin in Acute Coronary Syndrome Patients

  • Bashar J. Hussein Dept .of Biochemistry, College of Medicine, University of Baghdad.
  • Zina H. Abdul-Qahar Dept .of Biochemistry, College of Medicine, University of Baghdad.
  • Nazar N. Abbas Dept .of Cardiology, Baghdad Teaching Hospital.
Keywords: Acute Coronary Syndrome, Unstable angina, ST-segment elevation MI, Non-ST- segment elevation MI, Apelin.

Abstract

Background: Acute coronary syndrome refers to any group of clinical symptoms compatible with acute myocardial ischemia including unstable angina (UA), Non-ST-segment elevation myocardial infarction (NSTEMI) & ST-segment elevation myocardial infarction (STEMI).
Apelin is a novel endogenous peptide with inotropic and vasodilatory properties, it was recently reported that serum measurements of apelin were similar to its immunohistochemical data in vessels and heart tissues.
Objectives: This study aims to evaluate serum levels of apelin in patients with Acute Coronary Syndrome related to severity of presentation.
Patients and Methods: The present study was conducted during the period from September 2014 until March 2015. Fifty-nine patients with ACS were included as (30 UA, 15 NSTEMI, & 14 STEMI) patients. Also the study included (28) apparently healthy persons served as control. Blood samples were obtained for measurements of Apelin by ELISA method.
Results: Serum apelin levels were significantly decreased in whole group of patients with ACS (1846.1±320.9) ng/ml compared to control (2719.4±272.5) ng/ml (p< 0.05). Regarding patients’ subgroups; serum apelin was lowest in STEMI (1729.0±480.0) ng/ml, NSTEMI (1816.0±289.0) ng/ml, & UA (1916.0±224.4) ng/ml when compared with control; respectively.
Conclusion: Data obtained revealed a reduction in serum apelin levels in all patients groups especially STEMI, so it could be considered as a biochemical marker for evaluation of ACS.

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Published
2016-01-03
How to Cite
1.
Hussein B, Abdul-Qahar Z, Abbas N. Evaluation of Serum Apelin in Acute Coronary Syndrome Patients. JFacMedBagdad [Internet]. 3Jan.2016 [cited 6May2021];57(4):325-7. Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/401